COMPARATIVE-STUDY ON THE UPTAKE AND SUBSEQUENT DECARBOXYLATION OF MONO-AMINE PRECURSORS IN CEREBRAL MICROVESSELS

被引：25

作者：

HARDEBO, JE ^{[1
]}

FALCK, B ^{[1
]}

OWMAN, C ^{[1
]}

机构：

[1] UNIV LUND,DEPT NEUROL,S-22101 LUND,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 107卷 / 02期

关键词：

aromatic aminoacid decarboxylase; blood‐brain barrier; brain microvessels; monoamine oxidase;

D O I：

10.1111/j.1748-1716.1979.tb06456.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The endothelial cells and pericytes of brain microvessels (capillaries and small veins) are equipped with an enzymatic barrier, impeding the passage of circulating amino acids, such as amine precursors, into the brain. The properties of this mechanism was studied in brain slices and isolated microvessels from various species including man and also fetal material, following incubation in dihydroxyphenylalanine (DOPA), 5‐hydroxytryptophan (5‐HTP) and dihydroxyphenylserine (DOPS). A stereospecific, energy‐dependent uptake leading to accumulation in the brain microvessel walls was found in all species studied; this process was found to exist already prenatally. The capacity of decarboxylation, the second step in the trapping mechanism at the blood‐brain interphase, showed considerable species variation. The enzyme was present also in fetal brain microvessels. Inhibition experiments provided support for the presence of monoamine oxidase, but absence of catechol‐O‐methyl transferase, in the microvessel walls. © 1979 Scandinavian Physiological Society

引用

页码：161 / 167

页数：7

共 32 条

[1] UPTAKE AND METABOLISM OF [NOREPINEPHRINE-H-3] IN UTERINE NERVES OF PREGNANT GUINEA-PIG [J].