INVESTIGATION OF PROTEIN AMIDE-PROTON EXCHANGE BY H-1 LONGITUDINAL SPIN RELAXATION

被引：11
|
作者：
ZHENG, ZW
GRYK, MR
FINUCANE, MD
JARDETZKY, O
机构：
[1] Stanford Magnetic Resonance Laboratory, Stanford University, Stanford
来源：
JOURNAL OF MAGNETIC RESONANCE SERIES B | 1995年 / 108卷 / 03期
关键词：
D O I：
10.1006/jmrb.1995.1127
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
The general theory of the Linderstrom-Lang model, which, in simplified form, is widely used for the interpretation of NMR data on backbone-proton exchange in proteins, is systematically discussed. An experimental protocol for testing the applicability of the customary simplifications is described and experimental data which require the application of the general, rather than of the simplified, theory are presented. The appearance of pH-dependent biexponential magnetization recovery for any amide group in a protein is an unequivocal indication that the conventional simplified versions of the model do not apply. (C) 1995 Academic Press, Inc.
引用
收藏
页码：220 / 234
页数：15
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