PHENYLACETYL GROUP AS ENZYME-CLEAVABLE AMINOPROTECTION OF PURINE NUCLEOSIDES

被引：16

作者：

DINEVA, MA

GALUNSKY, B

KASCHE, V

PETKOV, DD

机构：

[1] TECH UNIV HAMBURG,AB BIOTECHNOL 2,D-21071 HAMBURG,GERMANY

[2] BULGARIAN ACAD SCI,INST ORGAN CHEM,BIOCATALYSIS LAB,BU-1113 SOFIA,BULGARIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

N-PHENYLACETYL PROTECTION; NUCLEOSIDES; NUCLEOTIDE SYNTHESIS; PENICILLIN AMIDASE;

D O I：

10.1016/S0960-894X(01)80763-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N6-Phenylacetyl-2'-deoxyadenosine and N2-Phenylacetyl-2'-deoxyguanosine are readily deprotected in reactions catalyzed by free and immobilized penicillin amidase at pH 7.8 and 25-degrees-C.

引用

页码：2781 / 2784

页数：4

共 14 条

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[6] KASCHE V, 1993, 17TH INT S COL LIQ C
[7] NUCLEOTIDE CHEMISTRY .12. N-6 (N-METHYL-2-PYRROLIDINE AMIDINE)DEOXYADENOSINE - A NEW DEOXYNUCLEOSIDE PROTECTING GROUP
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[8] THE ORGANIC-CHEMISTRY UNDERLYING DNA-SYNTHESIS
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[10] SVEDAS V, 1990, THESIS MV LOMONOSOV

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