METABOLITES OF THE TOBACCO-SPECIFIC NITROSAMINE 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE IN SMOKERS URINE

被引：0
|
作者：
CARMELLA, SG
AKERKAR, S
HECHT, SS
机构：
来源：
CANCER RESEARCH | 1993年 / 53卷 / 04期
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 mug/24 h, respectively. The results of this study provide the first evidence for metabolites of tobacco-specific nitrosamines in human urine.
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页码：721 / 724
页数：4
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