EFFECT OF METOCLOPRAMIDE ON PORTAL BLOOD-FLOW IN PATIENTS WITH LIVER-CIRRHOSIS, MEASURED BY THE PULSED DOPPLER SYSTEM

被引：6
作者：
LJUBICIC, N
机构：
[1] Dept. of Gastroenterology and Hepatology, Ultrasonic Institute, University of Zagreb, General Hospital Dr Josip Kajfeš, Zagreb, Yugoslavia
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷 / 10期
关键词：
Liver cirrhosis; Metoclopramide; Portal blood flow;
D O I：
10.3109/00365529008997626
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The effect of metoclopramide on portal blood flow, the maximal diameter of the portal vein, and some cardiovascular haemortynamic variables was studied in 10 patients with cirrhosis of the liver and portal hypertension. Portal vein haemo-dynamics were studied by the pulsed Doppler system. Within 15 min of intravenous administration of 20 mg metoclopramide, portal blood velocity and portal blood flow decreased significantly, from 11.2 ± 1.1 to 10.8 ± 1.2 cm/sec and from 769.0 ± 87.7 to 707.9 ± 84.2 ml/min, respectively (p < 0.001). Within about 30 min portal blood velocity and portal blood flow returned to basal values (p >0.05). The maximal diameter of the portal vein, systolic and diastolic blood pressure, and heart rate remained unchanged. These results support the hypothesis that metoclopramide, which raises lower oesophageal sphincter pressure and reduces intravariceal blood flow, significantly decreases the portal blood flow in cirrhotic patients with portal hypertension. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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收藏
页码：1004 / 1009
页数：6
相关论文
共 17 条
[1]  
ARONSEN KF, 1966, ACTA CHIR SCAND, V141, P433
[2]  
BOESBY S, 1974, SCAND J GASTROENTERO, V9, P587
[3]   DOMPERIDONE - A DRUG WITH POWERFUL ACTION ON THE LOWER ESOPHAGEAL SPHINCTER PRESSURE [J].
BRON, B ;
MASSIH, L .
DIGESTION, 1980, 20 (06) :375-378
[4]   MEASUREMENT OF NORMAL PORTAL VENOUS-BLOOD FLOW BY DOPPLER ULTRASOUND [J].
BROWN, HS ;
HALLIWELL, M ;
QAMAR, M ;
READ, AE ;
EVANS, JM ;
WELLS, PNT .
GUT, 1989, 30 (04) :503-509
[5]   PORTAL PRESSURE, PRESENCE OF GASTROESOPHAGEAL VARICES AND VARICEAL BLEEDING [J].
GARCIATSAO, G ;
GROSZMANN, RJ ;
FISHER, RL ;
CONN, HO ;
ATTERBURY, CE ;
GLICKMAN, M .
HEPATOLOGY, 1985, 5 (03) :419-424
[6]  
GILL R W, 1979, Ultrasound in Medicine and Biology, V5, P223, DOI 10.1016/0301-5629(79)90014-0
[7]  
GUELRUD M, 1974, AM J GASTROENTEROL, V61, P119
[8]   METOCLOPRAMIDE - AN UPDATED REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND CLINICAL USE [J].
HARRINGTON, RA ;
HAMILTON, CW ;
BROGDEN, RN ;
LINKEWICH, JA ;
ROMANKIEWICZ, JA ;
HEEL, RC .
DRUGS, 1983, 25 (05) :451-494
[9]   PHARMACOLOGICAL CONSTRICTION OF THE LOWER ESOPHAGEAL SPHINCTER - A SIMPLE METHOD OF ARRESTING VARICEAL HEMORRHAGE [J].
HOSKING, SW ;
DOSS, W ;
ELZEINY, H ;
ROBINSON, P ;
BARSOUM, MS ;
JOHNSON, AG .
GUT, 1988, 29 (08) :1098-1102
[10]   A RANDOMIZED CONTROLLED-STUDY OF PROPRANOLOL FOR PREVENTION OF RECURRENT GASTROINTESTINAL-BLEEDING IN PATIENTS WITH CIRRHOSIS - A FINAL REPORT [J].
LEBREC, D ;
POYNARD, T ;
BERNUAU, J ;
BERCOFF, E ;
NOUEL, O ;
CAPRON, JP ;
POUPON, R ;
BOUVRY, M ;
RUEFF, B ;
BENHAMOU, JP .
HEPATOLOGY, 1984, 4 (03) :355-358
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