Scientific Opinion on Dietary Reference Values for folate

被引：66

作者：

Agostoni, Carlo ^{[1
]}

Canani, Roberto Berni ^{[1
]}

Fairweather-Tait, Susan ^{[1
]}

Heinonen, Marina ^{[1
]}

Korhonen, Hannu ^{[1
]}

La Vieille, Sebastien ^{[1
]}

Marchelli, Rosangela ^{[1
]}

Martin, Ambroise ^{[1
]}

Naska, Androniki ^{[1
]}

Neuhaeuser-Berthold, Monika ^{[1
]}

Nowicka, Grazyna ^{[1
]}

Sanz, Yolanda ^{[1
]}

Siani, Alfonso ^{[1
]}

Sjodin, Anders ^{[1
]}

Stern, Martin ^{[1
]}

Strain, Sean ^{[1
]}

Tetens, Inge ^{[1
]}

Tome, Daniel ^{[1
]}

Turck, Dominique ^{[1
]}

Verhagen, Hans ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2014年 / 12卷 / 11期

关键词：

folate; folic acid; Average Requirement; Dietary Reference Value; health outcomes;

D O I：

10.2903/j.efsa.2014.3893

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for folate. The Panel concludes that an Average Requirement (AR), as well as a Population Reference Intake (PRI) assuming a coefficient of variation (CV) of 15 % to account for the additional variability associated with the higher requirement for folate in individuals with the methylene-tetrahydrofolate reductase (MTHFR) 677TT genotype, can be derived from biomarkers of folate status. Several health outcomes possibly associated with folate intake/status were also considered, but data were found to be insufficient to establish DRVs. For adults, the AR is determined from the folate intake required to maintain folate adequacy characterised by serum and red blood cell folate concentrations of = 10 and 340 nmol/L, respectively. An AR of 250 mu g dietary folate equivalents (DFE)/day and a PRI of 330 mu g DFE/day are derived. For infants aged 7-11 months, an Adequate Intake (AI) of 80 mu g DFE/day is derived by extrapolating upwards from the estimated folate intake in exclusively breast-fed infants. For children, ARs are extrapolated from the AR for adults using allometric scaling and growth factors and considering differences in reference weights. PRIs ranging from 120 mu g DFE/day for 1-3 year-old children to 330 mu g DFE/day for boys and girls aged 15-17 years are derived. For pregnant women, an AI of 600 mu g DFE/day is derived based on a study on maintenance of serum and red blood cell folate concentrations in pregnancy. For lactating women, an additional intake of 130 mu g DFE/day is considered to cover folate losses via breast milk; this figure is added to the AR for non-lactating women and a PRI of 500 mu g DFE/day is derived.

引用

页数：59

共 259 条

[1] Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women [J].