DIASTEREOISOMERICALLY PURE DINUCLEOSIDYLPHOSPHOROFLUORIDITES AND THEIR APPLICATION IN STEREOSPECIFIC SYNTHESIS OF DINUCLEOSIDYLPHOSPHOROFLUORIDOTHIONATES

被引：22

作者：

DABKOWSKI, W

TWOROWSKA, I

MICHALSKI, J

CRAMER, F

机构：

[1] POLISH ACAD SCI,CTR MOLEC & MACROMOLEC STUDIES,PL-90363 LODZ,POLAND

[2] MAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 14期

关键词：

D O I：

10.1039/c39950001435

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dinucleosidylphosphorofluoridites with dA(Bz), dC(Bz) or dT at the 3'-end and dT at the 5'-end are synthesised, separated into their diastereoisomers and shown to be converted stereospecifically into the corresponding phosphorofluoridothionates high hydrolytic stability.

引用

页码：1435 / 1436

页数：2

共 15 条

[1]

ABKOWSKI WD, 1995, TETRAHEDRON LETT, V7, P1095

[2]

BAECHLER RD, 1971, J AM CHEM SOC, V93, P773

[3] SILICON PHOSPHORUS ANALOGIES - FLUORIDE ACTIVATION OF NUCLEOPHILIC DISPLACEMENT AT THE TETRAHEDRAL PHOSPHORUS - AN EXAMPLE OF NUCLEOPHILIC ASSISTANCE TO NUCLEOPHILIC-SUBSTITUTION .3. [J].