CYTOKINE-TO-BRAIN COMMUNICATION - A REVIEW AND ANALYSIS OF ALTERNATIVE MECHANISMS

被引：468
作者：
WATKINS, LR [1 ]
MAIER, SF [1 ]
GOEHLER, LE [1 ]
机构：
[1] UNIV COLORADO, HLTH SCI CTR, DEPT CELLULAR & STRUCT BIOL, DENVER, CO 80262 USA
来源：
LIFE SCIENCES | 1995年 / 57卷 / 11期
关键词：
CYTOKINES; VAGUS; IMMUNE-TO-BRAIN COMMUNICATION; INTERLEUKIN-1; TUMOR NECROSIS FACTOR;
D O I：
10.1016/0024-3205(95)02047-M
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It is becoming well accepted that products of the immune system (cytokines) can signal the brain that infection has occurred. This cytokine-to-brain communication can result in marked alterations in brain function and behavior. This review examines alternative mechanisms that have been proposed to explain how such immune products can reach the brain via the blood to cause centrally-mediated ''illness'' responses. Finally, we describe a new view which argues that cytokines signal brain in quite a different manner, by stimulating afferent terminals of peripheral nerves at local sites of synthesis and release.
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收藏
页码：1011 / 1026
页数：16
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