EPIDEMIOLOGIC INVESTIGATION OF THE ASSOCIATION BETWEEN INFECTIOUS-MONONUCLEOSIS AND MULTIPLE-SCLEROSIS

被引：74
作者：
LINDBERG, C
ANDERSEN, O
VAHLNE, A
DALTON, M
RUNMARKER, B
机构：
[1] GOTHENBURG UNIV,DEPT NEUROL,S-41124 GOTHENBURG,SWEDEN
[2] GOTHENBURG UNIV,DEPT VIROL,S-41124 GOTHENBURG,SWEDEN
来源：
NEUROEPIDEMIOLOGY | 1991年 / 10卷 / 02期
关键词：
MULTIPLE SCLEROSIS; INFECTIOUS MONONUCLEOSIS; RISK FACTOR;
D O I：
10.1159/000110248
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
By matching a cohort of 494 infectious mononucleosis (IM) cases with a multiple sclerosis (MS) register, 3 MS cases were retrieved. The interval between IM and MS was 12 years. This corresponds to a relative risk of 3.7 for MS to occur subsequent to IM (p = 0.05). This relationship between a manifestation of a relatively late Epstein-Barr virus infection and MS may indicate that a microbiologically shielded environment is important in the pathogenesis of MS.
引用
收藏
页码：62 / 65
页数：4
相关论文
共 12 条
[1]   MULTIPLE-SCLEROSIS AND CHILDHOOD INFECTIONS [J].
ALTER, M ;
ZHANG, ZX ;
DAVANIPOUR, Z ;
SOBEL, E ;
ZIBULEWSKI, J ;
SCHWARTZ, G ;
FRIDAY, G .
NEUROLOGY, 1986, 36 (10) :1386-1389
[2]   MULTIPLE-SCLEROSIS AND CHILDHOOD INFECTIONS [J].
ALTER, M ;
CENDROWSKI, W .
NEUROLOGY, 1976, 26 (03) :201-204
[3]   THE MULTIPLE CAUSES OF MULTIPLE-SCLEROSIS - THE IMPORTANCE OF AGE OF INFECTIONS IN CHILDHOOD [J].
ALVORD, EC ;
JAHNKE, U ;
FISCHER, EH ;
KIES, MW ;
DRISCOLL, BF ;
COMPSTON, DAS .
JOURNAL OF CHILD NEUROLOGY, 1987, 2 (04) :313-321
[4]  
ANDERSEN E, 1981, ACTA NEUROL SCAND, V63, P131
[5]   VIRAL-INFECTION IN PATIENTS WITH MULTIPLE-SCLEROSIS AND HLA-DR MATCHED CONTROLS [J].
COMPSTON, DAS ;
VAKARELIS, BN ;
PAUL, E ;
MCDONALD, WI ;
BATCHELOR, JR ;
MIMS, CA .
BRAIN, 1986, 109 :325-344
[6]  
Evans AS., 1981, HUMAN HERPESVIRUSES, P172
[7]   THE PROBLEM OF EXOGENOUS CAUSATIVE FACTORS IN MULTIPLE-SCLEROSIS - PRELIMINARY-RESULTS OF A CONTROLLED INQUIRY IN THE EPIDEMIOLOGICAL AREA OF SOUTHERN HESSE [J].
FIRNHABER, W ;
LAUER, K .
AKTUELLE NEUROLOGIE, 1984, 11 (03) :82-85
[8]   A CASE-CONTROL STUDY OF MULTIPLE-SCLEROSIS [J].
OPERSKALSKI, EA ;
VISSCHER, BR ;
MALMGREN, RM ;
DETELS, R .
NEUROLOGY, 1989, 39 (06) :825-829
[9]  
PANELIUS M, 1973, ACTA NEUROL SCAND, V49, P85
[10]   NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].
POSER, CM ;
PATY, DW ;
SCHEINBERG, L ;
MCDONALD, WI ;
DAVIS, FA ;
EBERS, GC ;
JOHNSON, KP ;
SIBLEY, WA ;
SILBERBERG, DH ;
TOURTELLOTTE, WW .
ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231
12