THE SPECIFICITY OF OMEPRAZOLE AS AN (H+ + K+)-ATPASE INHIBITOR DEPENDS UPON THE MEANS OF ITS ACTIVATION

被引：61

作者：

KEELING, DJ

FALLOWFIELD, C

UNDERWOOD, AH

机构：

来源：

BIOCHEMICAL PHARMACOLOGY | 1987年 / 36卷 / 03期

关键词：

D O I：

10.1016/0006-2952(87)90291-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：339 / 344

页数：6

共 10 条

[1] THE PREPARATION OF C-14,S-35 AND C-13 LABELED FORMS OF OMEPRAZOLE [J].

CROWE, AM ;

IFE, RJ ;

MITCHELL, MB ;

SAUNDERS, D .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1986, 23 (01) :21-33

[2] SUBSTITUTED BENZIMIDAZOLES INHIBIT GASTRIC-ACID SECRETION BY BLOCKING (H++K+)ATPASE [J].

FELLENIUS, E ;

BERGLINDH, T ;

SACHS, G ;

OLBE, L ;

ELANDER, B ;

SJOSTRAND, SE ;

WALLMARK, B .

NATURE, 1981, 290 (5802) :159-161

[3] ACID ACTIVATION OF (H+-K+)-ATPASE INHIBITING 2-(2-PYRIDYLMETHYL-SULPHINYL)BENZIMIDAZOLES - ISOLATION AND CHARACTERIZATION OF THE THIOPHILIC ACTIVE PRINCIPLE AND ITS REACTIONS [J].

FIGALA, V ;

KLEMM, K ;

KOHL, B ;

KRUGER, U ;

RAINER, G ;

SCHAEFER, H ;

SENNBILFINGER, J ;

STURM, E .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (02) :125-127

[4] INHIBITION OF (H+ + K+)-ATPASE AND H+ ACCUMULATION IN HOG GASTRIC MEMBRANES BY TRIFLUOPERAZINE, VERAPAMIL AND 8-(N,N-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE [J].

IM, WB ;

BLAKEMAN, DP ;

MENDLEIN, J ;

SACHS, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 770 (01) :65-72

[5] STUDIES ON THE MECHANISM OF ACTION OF OMEPRAZOLE [J].

KEELING, DJ ;

FALLOWFIELD, C ;

MILLINER, KJ ;

TINGLEY, SK ;

IFE, RJ ;

UNDERWOOD, AH .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (16) :2967-2973

[6] THE MECHANISM FOR INHIBITION OF GASTRIC (H++K+)-ATPASE BY OMEPRAZOLE [J].

LORENTZON, P ;

EKLUNDH, B ;

BRANDSTROM, A ;

WALLMARK, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 817 (01) :25-32

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8] EVIDENCE FOR ACID-INDUCED TRANSFORMATION OF OMEPRAZOLE INTO AN ACTIVE INHIBITOR OF (H+ + K+)-ATPASE WITHIN THE PARIETAL-CELL [J].

WALLMARK, B ;

BRANDSTROM, A ;

LARSSON, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 778 (03) :549-558

[9]

WALLMARK B, 1980, J BIOL CHEM, V255, P5313

[10] ON REVERSIBILITY OF BINDING OF CARDIOTONIC STEROIDS TO A PARTIALLY PURIFIED (NA+K)-ACTIVATED ADENOSINETRIPHOSPHATASE FROM BEEF BRAIN [J].

YODA, A ;

HOKIN, LE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 40 (04) :880-&

← 1 →