INDUCTION OF INTERLEUKIN-2 RECEPTOR-ALPHA CHAIN EXPRESSION ON IMMATURE ACUTE MYELOCYTIC-LEUKEMIA CELLS

被引：8

作者：

NAKASE, K

KITA, K

ANAZAWA, H

HOSHINO, K

SHIRAKAWA, S

TANAKA, I

TSUDO, M

机构：

[1] MIE UNIV, SCH MED, DEPT INTERNAL MED, TSU, MIE 514, JAPAN

[2] SUZUKA KAISEI HOSP, DEPT INTERNAL MED, SUZUKA, JAPAN

[3] KYOTO UNICHIKA HOSP, DEPT INTERNAL MED, KYOTO, JAPAN

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 04期

关键词：

INTERLEUKIN-2 RECEPTOR ALPHA CHAIN; ACUTE MYELOCYTIC LEUKEMIA; CD7; HLA-DR; INTERLEUKIN-3;

D O I：

10.1016/0145-2126(94)90029-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leukemic cells from 27 adult patients with acute myelocytic leukemia (AML) were investigated to determine the cell surface inducibility of interleukin-2 receptor (IL-2R) in in vitro culture with and without interteukin-1 beta (IL-I beta). IL-2R alpha chain (IL-2R alpha) was induced on leukemic cells in 11 of 27 cases. Most of the cases could induce IL-2R alpha spontaneously without IL-I beta, while the IL-2R beta chain (IL-2R beta) did not appear on leukemic cells from any of the cases tested. AML cases expressing CD7 or HLA-DR antigen could induce IL-2R alpha more frequently than any other type of AML. Among interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF) and G-CSF, IL-3 showed a more prominent effect on DNA synthesis in IL-2R alpha inducible cases than in its uninducible cases. These results suggest that IL-2R alpha but not IL-2R beta was easily inducible on AML cells with immature characteristics.

引用

页码：269 / 274

页数：6