THE ORGANIZATION AND EXPRESSION OF THE HUMAN L7A RIBOSOMAL-PROTEIN GENE

被引：35
|
作者：
COLOMBO, P [1 ]
YON, J [1 ]
FRIED, M [1 ]
机构：
[1] IMPERIAL CANC RES FUND,DEPT EUKARYOT GENE ORG & EXPRESS,LONDON WC2A 3PX,ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1129卷 / 01期
关键词：
L7A RIBOSOMAL PROTEIN; TRANSCRIPTIONAL START SITE; GENOME ORGANIZATION; DNA SEQUENCE; (HUMAN);
D O I：
10.1016/0167-4781(91)90218-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The genomic structure and sequence of the human ribosomal protein L7a (rpL7a) and its transcriptional start sites have been determined. The gene contains eight exons and seven introns spread over 3179 bp. The human rpL7a gene is similar to other mammalian ribosomal protein genes in containing a short first exon, a short 5' untranslated leader and its transcriptional start sites at C residues embedded in a polypyrimidine tract. The 25 bp polypyrimidine tract containing the two human rpL7a start sites is the longest polypyrimidine tract so far observed for a mammalian ribosomal protein gene.
引用
收藏
页码：93 / 95
页数：3
相关论文
共 50 条
  • [1] HUMAN L7A RIBOSOMAL-PROTEIN - SEQUENCE, STRUCTURAL ORGANIZATION, AND EXPRESSION OF A FUNCTIONAL GENE
    DEFALCO, S
    RUSSO, G
    ANGIOLILLO, A
    PIETROPAOLO, C
    GENE, 1993, 126 (02) : 227 - 235
  • [2] THE ORGANIZATION AND EXPRESSION OF A MAIZE RIBOSOMAL-PROTEIN GENE FAMILY
    LARKIN, JC
    HUNSPERGER, JP
    CULLEY, D
    RUBENSTEIN, I
    SILFLOW, CD
    GENES & DEVELOPMENT, 1989, 3 (04) : 500 - 509
  • [3] RIBOSOMAL-PROTEIN L7A IS ENCODED BY A GENE (SURF-3) WITHIN THE TIGHTLY CLUSTERED MOUSE SURFEIT LOCUS
    GIALLONGO, A
    YON, J
    FRIED, M
    MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) : 224 - 231
  • [4] CDNA SEQUENCE OF THE HUMAN RIBOSOMAL LARGE SUBUNIT PROTEIN L7A
    ZIEMIECKI, A
    MUELLER, RG
    HYNES, NE
    KRIEG, J
    KOZMA, SC
    NUCLEIC ACIDS RESEARCH, 1988, 16 (21) : 10356 - 10356
  • [5] Down-regulation of ribosomal protein L7A in human osteosarcoma
    Zheng, Shui-er
    Yao, Yang
    Dong, Yang
    Lin, Feng
    Zhao, Hui
    Shen, Zan
    Sun, Yuan-jue
    Tang, Li-na
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2009, 135 (08) : 1025 - 1031
  • [6] Down-regulation of ribosomal protein L7A in human osteosarcoma
    Shui-er Zheng
    Yang Yao
    Yang Dong
    Feng Lin
    Hui Zhao
    Zan Shen
    Yuan-jue Sun
    Li-na Tang
    Journal of Cancer Research and Clinical Oncology, 2009, 135 : 1025 - 1031
  • [7] THE ORGANIZATION AND EXPRESSION OF THE SACCHAROMYCES-CEREVISIAE L4-RIBOSOMAL PROTEIN GENES AND THEIR IDENTIFICATION AS THE HOMOLOGS OF THE MAMMALIAN RIBOSOMAL-PROTEIN GENE-L7A
    YON, J
    GIALLONGO, A
    FRIED, M
    MOLECULAR & GENERAL GENETICS, 1991, 227 (01): : 72 - 80
  • [8] Modulation of expression of ribosomal protein L7a (rpL7a) by ethanol in human breast cancer cells
    Yunfeng Zhu
    Hong Lin
    Zheng Li
    Mei Wang
    Jia Luo
    Breast Cancer Research and Treatment, 2001, 69 : 29 - 38
  • [9] Modulation of expression of ribosomal protein L7a (rpL7a) by ethanol in human breast cancer cells
    Zhu, YF
    Lin, H
    Li, Z
    Wang, M
    Luo, J
    BREAST CANCER RESEARCH AND TREATMENT, 2001, 69 (01) : 29 - 38
  • [10] LOCALIZATION OF THE SURFEIT GENE-CLUSTER CONTAINING THE RIBOSOMAL-PROTEIN GENE L7A TO CHROMOSOME BANDS 9Q33-34
    YON, J
    PALMER, RW
    SHEER, D
    FRIED, M
    ANNALS OF HUMAN GENETICS, 1989, 53 : 149 - 155
12345