THE DOPAMINE HYPOTHESIS OF THE REINFORCING PROPERTIES OF COCAINE

被引：924
作者：
KUHAR, MJ [1 ]
RITZ, MC [1 ]
BOJA, JW [1 ]
机构：
[1] NIDA, ADDICT RES CTR, PHARMACOL BRANCH, BALTIMORE, MD 21224 USA
来源：
TRENDS IN NEUROSCIENCES | 1991年 / 14卷 / 07期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0166-2236(91)90141-G
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. This model suggests potential medications for treatment of cocaine abuse and dependence. Some, but not all, pharmacological data in humans support the hypothesis and additional experimentation is needed.
引用
收藏
页码：299 / 302
页数：4
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