REDUCED VIRULENCE OF CANDIDA-ALBICANS PHR1 MUTANTS

被引：66

作者：

GHANNOUM, MA

SPELLBERG, B

SAPORITOIRWIN, SM

FONZI, WA

机构：

[1] GEORGETOWN UNIV,MED CTR,SCH MED,DEPT IMMUNOL & MICROBIOL,WASHINGTON,DC 20007

[2] UNIV CALIF LOS ANGELES,HARBOR RES & EDUC INST,ST JOHNS CARDIOVASC RES CTR,DIV INFECT DIS,TORRANCE,CA 90509

[3] UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA 90024

[4] UNIV CALIF IRVINE,CALIF COLL MED,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 11期

关键词：

D O I：

10.1128/IAI.63.11.4528-4530.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida albicans mutants lacking PHR1 exhibit a pH-dependent morphogenic defect which is expressed at pH 7.5, a pH comparable to that of mammalian blood (S. M. Saporito-Irwin, C. E. Birse, P. S. Sypherd, and W.A. Fonzi, Mol. Cell. Biol. 15:601-613, 1995). The in vivo relevance of this expression pattern was tested in a mouse model of systemic candidiasis. A phr1/phr1 mutant was found to be less virulent than an isogenic Phr1(+) strain and exhibited altered morphological development in vivo. These results indicate that PHR1 contributes to the virulence of C. albicans.

引用

页码：4528 / 4530

页数：3

共 50 条

[41] THE UPTAKE OF AMINO-ACIDS BY ERG MUTANTS OF CANDIDA-ALBICANS
ANSARI, S
GUPTA, P
MAHANTY, SK
PRASAD, R
JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1993, 31 (05): : 377 - 386
[42] PROTOPLASTS FUSION HYBRIDS FROM CANDIDA-ALBICANS MORPHOLOGICAL MUTANTS
NOMBELA, C
POMES, R
GIL, C
CRC CRITICAL REVIEWS IN MICROBIOLOGY, 1987, 15 (01): : 79 - 85
[43] STEROLS FROM POLYENE-RESISTANT MUTANTS OF CANDIDA-ALBICANS
HAMILTONMILLER, JM
JOURNAL OF GENERAL MICROBIOLOGY, 1972, 73 (NOV): : 201 - +
[44] A COMPLEMENTATION ANALYSIS BY PARASEXUAL RECOMBINATION OF CANDIDA-ALBICANS MORPHOLOGICAL MUTANTS
GIL, C
POMES, R
NOMBELA, C
JOURNAL OF GENERAL MICROBIOLOGY, 1988, 134 : 1587 - 1595
[45] Reduced virulence of Candida albicans MKC1 mutants: A role for mitogen-activated protein kinase in pathogenesis
DiezOrejas, R
Molero, G
NavarroGarcia, F
Pla, J
Nombela, C
SanchezPerez, M
INFECTION AND IMMUNITY, 1997, 65 (02) : 833 - 837
[46] IDENTIFICATION OF CANDIDA-ALBICANS - FURTHER WORK ON THE RAPID IDENTIFICATION OF CANDIDA-ALBICANS
NEWTON, A
SHAW, ED
GOODE, CS
RIGGALL, FO
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1960, 35 (03) : 123 - 123
[47] Candida albicans septin mutants are defective for invasive growth and virulence
Warenda, AJ
Kauffman, S
Sherrill, TP
Becker, JA
Konopka, JB
INFECTION AND IMMUNITY, 2003, 71 (07) : 4045 - 4051
[48] Virulence and pathogenicity of a Candida albicans mutant with reduced filamentation
Peroumal, Doureradjou
Manohar, Kodavati
Patel, Shraddheya Kumar
Kumari, Premlata
Sahu, Satya Ranjan
Acharya, Narottam
CELLULAR MICROBIOLOGY, 2019, 21 (12)
[49] PATHOGENICITY OF CANDIDA-ALBICANS
RUCHEL, R
IMMUNITAT UND INFEKTION, 1991, 19 (04): : 108 - 111
[50] CANDIDA-ALBICANS SEPTICEMIAS
SCHUTTESANHUEZA, H
LAZOIZQUIERDO, M
FERRADAURZUA, L
RETAMALGIL, C
REVISTA CLINICA ESPANOLA, 1978, 149 (03): : 251 - 256

← 1 2 3 4 5 →