REDUCED VIRULENCE OF CANDIDA-ALBICANS PHR1 MUTANTS

被引：66

作者：

GHANNOUM, MA

SPELLBERG, B

SAPORITOIRWIN, SM

FONZI, WA

机构：

[1] GEORGETOWN UNIV,MED CTR,SCH MED,DEPT IMMUNOL & MICROBIOL,WASHINGTON,DC 20007

[2] UNIV CALIF LOS ANGELES,HARBOR RES & EDUC INST,ST JOHNS CARDIOVASC RES CTR,DIV INFECT DIS,TORRANCE,CA 90509

[3] UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA 90024

[4] UNIV CALIF IRVINE,CALIF COLL MED,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 11期

关键词：

D O I：

10.1128/IAI.63.11.4528-4530.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida albicans mutants lacking PHR1 exhibit a pH-dependent morphogenic defect which is expressed at pH 7.5, a pH comparable to that of mammalian blood (S. M. Saporito-Irwin, C. E. Birse, P. S. Sypherd, and W.A. Fonzi, Mol. Cell. Biol. 15:601-613, 1995). The in vivo relevance of this expression pattern was tested in a mouse model of systemic candidiasis. A phr1/phr1 mutant was found to be less virulent than an isogenic Phr1(+) strain and exhibited altered morphological development in vivo. These results indicate that PHR1 contributes to the virulence of C. albicans.

引用

页码：4528 / 4530

页数：3

共 11 条

[1]

BULAWA C, 1995, NATIONAL COOPERATIVE

[2]

CUTLER JE, 1992, ANNU REV MICROBIOL, V45, P187

[3]

FONZI WA, 1993, GENETICS, V134, P717

[4]

GHANNOUM MA, 1985, MYKOSEN, V28, P369