LONG-TERM SURVIVAL IN A PATIENT WITH MALIGNANT CARCINOID TREATED WITH HIGH-DOSE OCTREOTIDE

被引：10

作者：

DEGUCHI, H ^{[1
]}

DEGUCHI, K ^{[1
]}

TSUKADA, T ^{[1
]}

MURASHIMA, S ^{[1
]}

IWASAKI, E ^{[1
]}

TSUDA, M ^{[1
]}

KOBAYASHI, T ^{[1
]}

SHIRAKAWA, S ^{[1
]}

机构：

[1] MATUSAKA CHUO HOSP,DEPT INTERNAL MED,KAMATA CHO 145,MATUSAKA,MIE 515,JAPAN

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 02期

关键词：

INTERFERON; CARCINOID CRISIS;

D O I：

10.2169/internalmedicine.33.100

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Octreotide acetate, a long-acting somatostatin analogue, is effective in controlling and markedly reducing the symptoms of carcinoid crisis. We report a patient with carcinoid syndrome with prolonged survival for 4.5 years with high dose octreotide therapy and survived for 7.5 years after the first flushing, in spite of episodes of severe carcinoid crisis. Dose escalation was required in order to control carcinoid symptoms, and the final dosage was 5,950 mug/day. Although administration of such a high dosage of octreotide has never been reported before, we found that octreotide could be used at this dosage safely without inducing serious side effects, and probably prolonged the patient's survival. Our experience with this case indicates that octreotide acetate is an effective drug in controlling carcinoid crisis and prolonging survival without serious side effects.

引用

页码：100 / 102

页数：3

共 10 条

[1] Goodwin J.D., Carcinoid tumors: an analysis 2837 cases, Cancer, 36, (1975)
[2] McCrirrick A., Hickman J., Octreotide for carcinoid syndrome, Can J Anaesth, 38, (1991)
[3] Kvolus L.K., The carcinoid syndrome: a treatable malignant disease, Oncology, 2, (1988)
[4] ANONYMOUS. Octreotide a synthetic somatostatin, Med Lett Drugs Ther, 31, (1989)
[5] Vink A.I., Thompson N., Echauser F., Moattari A.R., Clinical features of carcinoid syndrome and the use of somatostatin analogue in its management, Acta Oncol, 28, (1989)
[6] Altman A.R., Tschen J.A., Rice L., Treatment of carcinoid syndrome with a long-acting somatostatin analogue, Arch Dermatol, 125, (1989)
[7] Deghenghi R., Somatostatin analogues in the treatment of the carcinoid syndrome, Biomed Pharmacother, 42, (1989)
[8] Jerome M.F., Carcinoid tumors and the carcinoid syndrome, Curr Probl Surg, 12, (1989)
[9] Coupe M., Levi S., Ellis B., Et al., Therapy for symptoms in the carcinoid syndrome, Q J Med, 73, (1989)
[10] Tanaka K., Ito Y., Simizu N., Clinical application of somatostatin-analogue, Nihonrinsyou, 48, (1990)

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