DEVELOPMENT OF NEW DNA-BINDING AND CLEAVING MOLECULES - DESIGN, SYNTHESIS AND ACTIVITY OF A BISDIAZONIUM SALT

被引：22

作者：

ARYA, DP ^{[1
]}

WARNER, PM ^{[1
]}

JEBARATNAM, DJ ^{[1
]}

机构：

[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61485-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 mu M. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving reagent.

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页码：7823 / 7826

页数：4

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