EFFECTS OF SOME GABAERGIC AGENTS ON QUININE-INDUCED SEIZURES IN MICE

被引：11

作者：

AMABEOKU, GJ

CHIKUNI, O

机构：

[1] Department of Clinical Pharmacology, Medical School, University of Zimbabwe, Harare, Avondale

来源：

EXPERIENTIA | 1992年 / 48卷 / 07期

关键词：

QUININE; SEIZURES; GABAERGIC AGENTS; GABAERGIC MECHANISM; DIAZEPAM; PHENOBARBITONE; PHENYTOIN;

D O I：

10.1007/BF02118313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective effects of muscimol, AOAA and DABA against convulsions induced by quinine. Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine. However, phenytoin did not affect quinine-induced seizures to any significant degree. These results indicate that the convulsant effect of quinine may be due to a disturbance in the status of the GABAergic system.

引用

页码：659 / 662

页数：4

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