LIPID-PROTEIN-PARTITIONING THEORY OF SKIN PENETRATION ENHANCEMENT

被引：232
作者：
BARRY, BW
机构：
[1] Postgraduate Studies in Pharmaceutical Technology, School of Pharmacy, University of Bradford, Bradford
来源：
JOURNAL OF CONTROLLED RELEASE | 1991年 / 15卷 / 03期
关键词：
LIPID-PROTEIN-PARTITIONING THEORY; PENETRATION ENHANCERS; SKIN PERMEATION; DIFFERENTIAL SCANNING CALORIMETRY; STRATUM-CORNEUM;
D O I：
10.1016/0168-3659(91)90115-T
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Lipid-Protein-Partitioning theory of skin penetration enhancement suggests that accelerants usually act by one or more of three main mechanisms; they can alter the intercellular lipid or intracellular protein domains of the horny layer and they may also increase partitioning into the skin of a drug, a co-enhancer, water or any combination of these. This paper discusses these concepts, quoting examples of the three mechanisms as assessed by differential scanning calorimetry and permeation studies and relates such investigations to our ideas of the molecular architecture of the stratum corneum.
引用
收藏
页码：237 / 248
页数：12
相关论文
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