GLOBAL-ISCHEMIA INDUCES NMDA RECEPTOR-MEDIATED C-FOS EXPRESSION IN NEURONS RESISTANT TO INJURY IN GERBIL HIPPOCAMPUS

被引：97

作者：

UEMURA, Y

KOWALL, NW

BEAL, MF

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114

[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,EXPTL NEUROPATHOL LAB,BOSTON,MA 02114

[3] HARVARD UNIV,MASSACHUSETTS GEN HOSP,NEUROCHEM LAB,BOSTON,MA 02114

[4] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114

[5] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114

来源：

BRAIN RESEARCH | 1991年 / 542卷 / 02期

关键词：

C-FOS; N-METHYL-D-ASPARTATE RECEPTOR; DELAYED NEURONAL DEATH; GLOBAL ISCHEMIA; GERBIL;

D O I：

10.1016/0006-8993(91)91589-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The induction of c-fos protein-like immunoreactivity (CFPLI) was examined in the hippocampus of gerbils at several time points after transient global ischemia. c-Fos protein induction was largely confined to the dentate gyrus, CA3 and CA4 regions from 2 to 8 h after transient bilateral carotid occlusion. Little CFPLI was seen in the CA1 subfield, which is disproportionately sensitive to injury after global ischemia. c-Fos induction was completely blocked by pretreatment with MK-801 (3 mg/kg). Our results show that c-fos expression after global ischemia is NMDA receptor mediated, and mainly found in hippocampal neurons resistant to ischemic injury.

引用

页码：343 / 347

页数：5

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