GLOBAL-ISCHEMIA INDUCES NMDA RECEPTOR-MEDIATED C-FOS EXPRESSION IN NEURONS RESISTANT TO INJURY IN GERBIL HIPPOCAMPUS

被引：97
|
作者：
UEMURA, Y
KOWALL, NW
BEAL, MF
机构：
[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114
[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,EXPTL NEUROPATHOL LAB,BOSTON,MA 02114
[3] HARVARD UNIV,MASSACHUSETTS GEN HOSP,NEUROCHEM LAB,BOSTON,MA 02114
[4] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114
[5] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT NEUROSURG,BOSTON,MA 02114
来源：
BRAIN RESEARCH | 1991年 / 542卷 / 02期
关键词：
C-FOS; N-METHYL-D-ASPARTATE RECEPTOR; DELAYED NEURONAL DEATH; GLOBAL ISCHEMIA; GERBIL;
D O I：
10.1016/0006-8993(91)91589-S
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The induction of c-fos protein-like immunoreactivity (CFPLI) was examined in the hippocampus of gerbils at several time points after transient global ischemia. c-Fos protein induction was largely confined to the dentate gyrus, CA3 and CA4 regions from 2 to 8 h after transient bilateral carotid occlusion. Little CFPLI was seen in the CA1 subfield, which is disproportionately sensitive to injury after global ischemia. c-Fos induction was completely blocked by pretreatment with MK-801 (3 mg/kg). Our results show that c-fos expression after global ischemia is NMDA receptor mediated, and mainly found in hippocampal neurons resistant to ischemic injury.
引用
收藏
页码：343 / 347
页数：5
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