REGULATION OF TRH RELEASE BY THE CULTURED NEONATE RAT PANCREAS

被引：8
作者：
DUTOUR, A
GIRAUD, P
MALTESE, JY
BECQUET, D
PESCE, G
SALERS, P
OUAFIK, L
RENARD, M
OLIVER, C
机构：
[1] Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, 13326 Marseille Cédex 15, Bd P. Dramard
来源：
PEPTIDES | 1990年 / 11卷 / 06期
关键词：
TRH; ENDOCRINE PANCREAS; PERINATAL PERIOD; MECHANISMS OF PANCREATIC TRH SECRETION;
D O I：
10.1016/0196-9781(90)90134-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The TRH secretory responsiveness of the pancreatic islet cell clusters from newborn rat in organ culture was studied. Basal TRH secretion was stable over a 9-day period. The response to various secretagogues was tested on day 4. TRH secretion was stimulated by high potassium-induced depolarization and also through both cAMP and protein kinase-C dependent pathways. Like insulin, TRH release was stimulated by glucose and arginine and inhibited by somatostatin. These date suggest the existence of a common mechanism for TRH and insulin secretion by the pancreatic beta-cells.
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页码：1081 / 1085
页数：5
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