GLYCATION ACCELERATES THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY COPPER IONS

被引：69
|
作者：
KOBAYASHI, K
WATANABE, J
UMEDA, F
NAWATA, H
机构：
[1] The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
来源：
ENDOCRINE JOURNAL | 1995年 / 42卷 / 04期
关键词：
LOW DENSITY LIPOPROTEIN; OXIDATION; GLYCATION; COPPER ION;
D O I：
10.1507/endocrj.42.461
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the in vitro effect of glycation on LDL oxidation. Native LDL (nLDL) was glycated in 0, 5, 10, or 20 mM glucose. This glycated LDL (gLDL) was oxidized by 1 mu M copper ion. Compared to nLDL and gLDL, oxidized gLDL (ogLDL) has a greater negative charge. The thiobarbituric acid reactive substance (TBARS) value of ogLDL increased with the glucose concentration tested during glycation in a dose-dependent manner. OgLDL glycated in 20 mM glucose had a significantly higher TEARS level than did oxidized LDL incubated without glucose. In conclusion, LDL glycated in vitro is prone to oxidation. Thus, glycated LDL, which increases in the diabetic state, may contribute to the pathogenesis of atherosclerosis in diabetic patients.
引用
收藏
页码：461 / 465
页数：5
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