INHIBITION OF ICE FAMILY PROTEASES BY BACULOVIRUS ANTIAPOPTOTIC PROTEIN P35

被引：581
作者：
BUMP, NJ
HACKETT, M
HUGUNIN, M
SESHAGIRI, S
BRADY, K
CHEN, P
FERENZ, C
FRANKLIN, S
GHAYUR, T
LI, P
LICARI, P
MANKOVICH, J
SHI, LF
GREENBERG, AH
MILLER, LK
WONG, WW
机构：
[1] BASF BIORES CORP, WORCESTER, MA 01605 USA
[2] UNIV GEORGIA, DEPT ENTOMOL, ATHENS, GA 30602 USA
[3] UNIV GEORGIA, DEPT GENET, ATHENS, GA 30602 USA
[4] UNIV MANITOBA, MANITOBA INST CELL BIOL, WINNIPEG, MB R3E 0V9, CANADA
来源：
SCIENCE | 1995年 / 269卷 / 5232期
关键词：
D O I：
10.1126/science.7569933
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICD) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation on ICE from its precursor form and blocked ICE-induced apoptosis, Inhibition of enzymatic activity correlated with the cleavage of p35 and the formation of a stable ICE-p35 complex. The ability of p35 to block apoptosis in different pathways and in distantly related organisms suggests a central and conserved role for ICE-like proteases in the induction of apoptosis.
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页码：1885 / 1888
页数：4
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