ESTIMATE OF THE WAVELENGTH DEPENDENCY OF ULTRAVIOLET CARCINOGENESIS IN HUMANS AND ITS RELEVANCE TO THE RISK ASSESSMENT OF A STRATOSPHERIC OZONE DEPLETION

被引：162
作者：
DEGRUIJL, FR
VANDERLEUN, JC
机构：
[1] University Hospital Utrecht, Utrecht, P.O. Box 85500
来源：
HEALTH PHYSICS | 1994年 / 67卷 / 04期
关键词：
ULTRAVIOLET RADIATION; CANCER; OZONE; RADIATION; NONIONIZING;
D O I：
10.1097/00004032-199410000-00001
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The wavelength dependency of carcinogenesis is an important factor in risk assessments pertaining to sources of ultraviolet radiation, the most important of which is the sun. This wavelength dependency cannot be measured directly in humans, but it has been measured in hairless mice, and represented in an action spectrum. An estimate of the action spectrum for humans can be produced by correcting for differences in epidermal transmission between mice and humans. This carcinogenic action spectrum for humans resembles the action spectrum for ultraviolet-induced erythema (sunburn), and results in small adjustments of earlier estimates of the effects of a stratospheric ozone depletion on skin cancer incidences.
引用
收藏
页码：319 / 325
页数：7
相关论文
共 28 条
[21]  
SCOTTO J, 1981, NIH822433 US DEP HLT
[22]   WAVELENGTHS IN SUNLIGHT EFFECTIVE IN PRODUCING SKIN CANCER - THEORETICAL ANALYSIS [J].
SETLOW, RB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3363-3366
[23]  
STERENBORG HJC, 1987, PHOTODERMATOLOGY, V5, P71
[24]  
VANDERLEUN JC, 1975, CLIMATIC IMPACT ASSE, V5, P107
[25]  
VANKRANEN HJ, 1992, 6TH P P53 WORKSH RE, P116
[26]  
VITASA BC, 1990, CANCER, V65, P2811, DOI 10.1002/1097-0142(19900615)65:12<2811::AID-CNCR2820651234>3.0.CO
[27]  
2-U
[28]   MUTATION HOTSPOTS DUE TO SUNLIGHT IN THE P53 GENE OF NONMELANOMA SKIN CANCERS [J].
ZIEGLER, A ;
LEFFELL, DJ ;
KUNALA, S ;
SHARMA, HW ;
GAILANI, M ;
SIMON, JA ;
HALPERIN, AJ ;
BADEN, HP ;
SHAPIRO, PE ;
BALE, AE ;
BRASH, DE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4216-4220
123