OPTICALLY-ACTIVE FLUORINATED BETA-LACTAM BUILDING-BLOCKS - A NOVEL FLUORINATED RETROAMIDE ISOSTERE

被引：16

作者：

ABOUABDELLAH, A ^{[1
]}

WELCH, JT ^{[1
]}

机构：

[1] SUNY ALBANY,DEPT CHEM,ALBANY,NY 12222

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 06期

关键词：

D O I：

10.1016/0957-4166(94)80050-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new and versatile synthesis of optically active alpha-fluoro-malonamides derivatives from enantiomerically pure 3-fluoro-2-azetidinones is described. A fluorinated retroamide isostere based on these alpha-fluoro-malonamide was introduced into a small peptidomimetic for use as an HIV-1 protease inhibitor.

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页码：1005 / 1013

页数：9

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