OPTICALLY-ACTIVE FLUORINATED BETA-LACTAM BUILDING-BLOCKS - A NOVEL FLUORINATED RETROAMIDE ISOSTERE

被引：16
|
作者：
ABOUABDELLAH, A [1 ]
WELCH, JT [1 ]
机构：
[1] SUNY ALBANY,DEPT CHEM,ALBANY,NY 12222
来源：
TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 06期
关键词：
D O I：
10.1016/0957-4166(94)80050-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new and versatile synthesis of optically active alpha-fluoro-malonamides derivatives from enantiomerically pure 3-fluoro-2-azetidinones is described. A fluorinated retroamide isostere based on these alpha-fluoro-malonamide was introduced into a small peptidomimetic for use as an HIV-1 protease inhibitor.
引用
收藏
页码：1005 / 1013
页数：9
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