BIOTRANSFORMATION AND URINARY-EXCRETION OF 4-SUBSTITUTED AMPHETAMINES IN PREGNANT MICE

被引:5
|
作者
FOSTER, BC
LITSTER, DL
BUTTAR, HS
DAWSON, B
ZAMECNIK, J
机构
[1] Bureau of Drug Research, Sir Frederick Banting Research Centre, Health Protection Branch, Ottawa, Ontario
关键词
METHOXYAMPHETAMINE; AMPHETAMINE; PREGNANCY; MOUSE; BIOTRANSFORMATION; METABOLISM;
D O I
10.1002/bdd.2510140807
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The urinary elimination of 4-hydroxyamphetamine (PHA) and a series of homologous 4-alkoxy-substituted amphetamines and their metabolites was examined after single and multiple oral administration to pregnant and non-pregnant mice. The metabolic profile and extent of biotransformation in a series of alkoxy analogues were affected by the size of the alkoxy side chain, multiple dosing and pregnancy. There were increased recoveries of both the substrate and the conjugated derivative of PHA during gestation. The major metabolic routes observed were O-dealkylation, conjugation, and aliphatic hydroxylation of the propoxy side chain. There was some evidence of oxidative deamination. Pregnancy did not alter the profile of the major metabolites detected by GLC and NMR spectroscopy.
引用
收藏
页码:709 / 719
页数:11
相关论文
共 50 条
  • [31] EFFECT OF FUROSEMIDE ON URINARY-EXCRETION OF 4-HYDROXY-3-METHOXYMANDELIC ACID (VMA)
    BURSZTYN, M
    GUTMAN, A
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1985, 21 (09): : 742 - 744
  • [32] CORRELATION OF URINARY-EXCRETION WITH INVITRO DISSOLUTION USING 4 DISSOLUTION METHODS FOR AMPICILLIN CAPSULES
    MORTADA, LM
    ISMAIL, FA
    KHALIL, SA
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1985, 11 (01) : 101 - 130
  • [33] SIGNIFICANCE OF URINARY-EXCRETION OF TRIIODOTHYRONINE (T3) AND THYROXINE (T4)
    RASTOGI, GK
    SAWHNEY, RC
    INDIAN JOURNAL OF MEDICAL RESEARCH, 1976, 64 (11) : 1639 - 1648
  • [34] HUMAN URINARY-EXCRETION OF HERBICIDE 2-METHYL-4-CHLOROPHENOXY ACETIC ACID
    FJELDSTAD, P
    WANNAG, A
    SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1977, 3 (02) : 100 - 103
  • [35] URINARY-EXCRETION OF TRIIODOTHYRONINE (T3) AND THYROXINE (T4) IN MAN
    BURKE, CW
    FRASER, TR
    GRAVES, L
    SHAKESPEARE, RA
    JOURNAL OF PHYSIOLOGY-LONDON, 1973, 231 (02): : P62 - P62
  • [36] COMPARISON OF URINARY-EXCRETION OF 4 LYSOSOMAL HYDROLASES IN HEALTHY ELDERLY AND YOUNG-ADULTS
    VANDERJAGT, DJ
    STEINBERG, BR
    GLEW, RH
    CLINICA CHIMICA ACTA, 1992, 210 (1-2) : 47 - 54
  • [37] NON-PROTEIN-BOUND ESTROGENS IN PLASMA AND URINARY-EXCRETION OF UNCONJUGATED ESTROGENS IN NON-PREGNANT WOMEN
    SPEIGHT, AC
    HANCOCK, KW
    OAKEY, RE
    JOURNAL OF ENDOCRINOLOGY, 1979, 83 (03) : 385 - 391
  • [38] URINARY-EXCRETION OF BIOLOGICALLY-ACTIVE CHORIONIC-GONADOTROPIN BY PREGNANT MARMOSET (CALLITHRIX-JACCHUS-JACCHUS)
    HOBSON, BM
    HEARN, JP
    LUNN, SF
    FLOCKHART, JH
    FOLIA PRIMATOLOGICA, 1977, 28 (04) : 251 - 258
  • [39] CIRCADIAN RHYTHMIC URINARY-EXCRETION OF THYROXINE (T4) IN HEALTHY-SUBJECTS
    VALVERDE, C
    LEGARRETA, G
    ACEVES, C
    SANCHEZ, DS
    HALBERG, F
    CHRONOBIOLOGIA, 1981, 8 (02) : 184 - 184
  • [40] URINARY-EXCRETION OF 3-METHOXY-4-HYDROXYPHENYLGLYCOL IN ACUTE MYOCARDIAL-INFARCTION
    WOCIAL, B
    SZNAJDERMAN, M
    JANUSZEWICZ, W
    RACZYNSKI, J
    CLINICA CHIMICA ACTA, 1979, 95 (03) : 517 - 520