PRODUCTION OF MULTIPLE GROWTH-FACTORS BY A HUMAN NONSMALL CELL LUNG-CARCINOMA CELL-LINE

被引：7

作者：

OCCLESTON, NL ^{[1
]}

WALKER, C ^{[1
]}

机构：

[1] CLATTERBRIDGE HOSP,JK DOUGLAS CANC RES LABS,CLATTERBRIDGE CANC RES TRUST,BEBINGTON L63 4JY,ENGLAND

来源：

CANCER LETTERS | 1993年 / 71卷 / 1-3期

关键词：

GROWTH FACTORS; ENDOTHELIAL CELLS; NONSMALL CELL LUNG CANCER;

D O I：

10.1016/0304-3835(93)90117-R

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The IPT cell line, derived from an undifferentiated bronchial carcinoma, produced, in conditioned medium, immunoreactive basic fibroblast growth factor (bFGF), insulin-like growth factors I and II (IGF-I and IGF-II), epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha), and transforming growth factor beta-2 (TGFbeta2) in its latent form, but not platelet-derived growth factor (PDGF), tumour necrosis factor alpha (TNFalpha), or transforming growth factor beta-1 (TGFbeta1). Comparative studies of growth stimulation of human umbilical vein (HUV) endothelial cells indicated that the growth factors detected in 1PT-conditioned medium do not solely account for its proliferative effects on these cells. These results support previous characterization studies [1,2] that suggest the production of a potentially novel tumour-derived endothelial cell growth factor by the 1PT cell line.

引用

页码：203 / 210

页数：8

共 35 条

[1] PURIFICATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR [J].