RHEUMATOID-ARTHRITIS - OPPOSING ACTIONS OF HEMATOPOIETIC GROWTH-FACTORS AND SLOW-ACTING ANTIRHEUMATIC DRUGS

被引：92

作者：

HAMILTON, JA

机构：

[1] University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville

来源：

LANCET | 1993年 / 342卷 / 8870期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0140-6736(93)91653-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogenesis of rheumatoid arthritis and the mode of action of anti-rheumatic drugs are unknown. This hypothesis proposes that haemopoietic growth factors (colony stimulating factors [CSFs]) have an important role in rheumatoid arthritis as regulators of myelopoiesis and as activators of inflammatory leucocytes. It also suggests that slow-acting anti-rheumatic drugs may work by inhibiting myelopoiesis. This opposition to one of the actions of the CSFs would result in fewer inflammatory cells in the inflamed joints.

引用

页码：536 / 539

页数：4

共 40 条

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[2]

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[3]

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