SESQUITERPENE-DERIVED METABOLITES FROM THE DEEP-WATER MARINE SPONGE POECILLASTRA-SOLLASI

被引：18
|
作者：
KILLDAY, KB
LONGLEY, R
MCCARTHY, PJ
POMPONI, SA
WRIGHT, AE
机构：
[1] HARBOR BRANCH OCEANOG INST INC,DIV BIOMED MARINE RES,5600 OLD DIXIE HIGHWAY,FT PIERCE,FL 34946
[2] CIBA GEIGY CORP,RES DEPT,SUMMIT,NJ 07901
来源：
JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 04期
关键词：
D O I：
10.1021/np50094a008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
SiX sesquiterpene-derived compounds, 1-6, which we call sollasins a-f, have been isolated from a deep water specimen of the sponge Poecillastra sollasi. The structures were elucidated by comparison of spectral data to related metabolites and confirmed using spectroscopic methods. The compounds inhibit the growth of the pathogenic fungi Candida albicans and Cryptococcus neoformans and the P-388 and A-549 tumor cell lines. Compounds 3 and 4 show weak inhibition of binding of [I-125] angiotensin II to rat aorta smooth muscle cell membranes.
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页码：500 / 507
页数：8
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