SELECTIVE-INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION BY SYMPATHECTOMY IN RABBIT CAROTID-ARTERY RINGS INVITRO

被引：0
作者：
KARS, HZ
UTKAN, T
SARIOGLU, Y
YARADANAKUL, V
机构：
[1] CUMHURIYET UNIV,SCH MED,DEPT NEUROSURG,SIVAS,TURKEY
[2] CUMHURIYET UNIV,SCH MED,DEPT PHARMACOL,SIVAS,TURKEY
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1993年 / 15卷 / 01期
关键词：
CAROTID ARTERIES; ENDOTHELIUM-DERIVED RELAXING FACTOR; SYMPATHECTOMY; VASOCONSTRICTION; VASODILATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of cervical and periarterial sympathectomy on endothelium-dependent relaxation of the rabbit common carotid artery was studied in vitro. Noradrenaline, serotonin, acetylcholine and papaverine concentration-response curves of sympathectomized and control rabbit common carotid artery rings were recorded and analyzed and effects of endothelium removal were investigated. Endothelium-dependent relaxation was selectively and significantly inhibited in 3 weeks postsympathectomy arterial preparations. Alterations in acetylcholine receptors of endothelial cells, decrease in endothelium-derived relaxing factor synthesis, or desensitization of medial muscular cells to endothelium-derived relaxing factor are hypothetical causes of this phenomenon.
引用
收藏
页码：35 / 40
页数：6
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