SELECTIVE-INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION BY SYMPATHECTOMY IN RABBIT CAROTID-ARTERY RINGS INVITRO

被引：0

作者：

KARS, HZ

UTKAN, T

SARIOGLU, Y

YARADANAKUL, V

机构：

[1] CUMHURIYET UNIV,SCH MED,DEPT NEUROSURG,SIVAS,TURKEY

[2] CUMHURIYET UNIV,SCH MED,DEPT PHARMACOL,SIVAS,TURKEY

来源：

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1993年 / 15卷 / 01期

关键词：

CAROTID ARTERIES; ENDOTHELIUM-DERIVED RELAXING FACTOR; SYMPATHECTOMY; VASOCONSTRICTION; VASODILATION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of cervical and periarterial sympathectomy on endothelium-dependent relaxation of the rabbit common carotid artery was studied in vitro. Noradrenaline, serotonin, acetylcholine and papaverine concentration-response curves of sympathectomized and control rabbit common carotid artery rings were recorded and analyzed and effects of endothelium removal were investigated. Endothelium-dependent relaxation was selectively and significantly inhibited in 3 weeks postsympathectomy arterial preparations. Alterations in acetylcholine receptors of endothelial cells, decrease in endothelium-derived relaxing factor synthesis, or desensitization of medial muscular cells to endothelium-derived relaxing factor are hypothetical causes of this phenomenon.

引用

页码：35 / 40

页数：6

共 30 条

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