CHONDROITIN SULFATE AS A REGULATOR OF NEURONAL PATTERNING IN THE RETINA

被引：386
|
作者：
BRITTIS, PA
CANNING, DR
SILVER, J
机构：
[1] Department of Neuroscienccs, Case Western Reserve University, Cleveland
来源：
SCIENCE | 1992年 / 255卷 / 5045期
关键词：
D O I：
10.1126/science.1738848
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Highly sulfated proteoglycans are correlated with axon boundaries in the developing central nervous system which suggests that these molecules affect neural pattern formation. In the developing mammalian retina, gradual regression of chondroitin sulfate may help control the onset of ganglion cell differentiation and initial direction of their axons. Changes induced by the removal of chondroitin sulfate from intact retinas in culture confirm the function of chondroitin sulfate in retinal histogenesis.
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页码：733 / 736
页数：4
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