INHIBITION OF ESCHERICHIA-COLI DNA-POLYMERASE-I CATALYZED DNA POLYMERIZATION BY TRANS-IMIDAZOLIUM-BISIMIDAZOLETETRACHLORORUTHENATE(III)

被引：0

作者：

HOLLER, E ^{[1
]}

SCHALLER, W ^{[1
]}

KEPPLER, B ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ANORGAN CHEM,W-6900 HEIDELBERG,GERMANY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1991年 / 41-2卷 / 10期

关键词：

CHEMOTHERAPEUTICS; DNA SYNTHESIS; INHIBITION; TRANS-IMIDAZOLIUM-BISIMIDAZOLETETRACHLORORUTHENATE(III);

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The tumor-inhibiting metal complex trans-imidazolium-bisimidazoletetrachlororuthenate(III) (ICR) reacts with DNA and inhibits template-primer properties for DNA synthesis catalysed by Escherichia coli DNA polymerase I. The reaction with DNA depends on the aging (half-life 6.8 h) of the aqueous solution containing ICR. The kinetics of the reaction with DNA are reminiscent of those for cisplatin.

引用

页码：1065 / 1068

页数：4

共 2 条

[1] APHIDICOLIN INHIBITS DNA POLYMERIZING ACTIVITY BUT NOT NUCLEOLYTIC ACTIVITY OF ESCHERICHIA-COLI DNA POLYMERASE-II
ISHINO, Y
IWASAKI, H
FUKUI, H
MINENO, J
KATO, I
SHINAGAWA, H
BIOCHIMIE, 1992, 74 (02) : 131 - 136
[2] DIFFERENTIAL INHIBITION OF ABORTIVE TRANSCRIPTION INITIATION AT DIFFERENT PROMOTERS CATALYZED BY ESCHERICHIA-COLI RNA-POLYMERASE - EFFECT OF RIFAMPICIN ON PURINE OR PYRAMIDINE-INITIATED PHOSPHODIESTER SYNTHESIS
KUMAR, KP
CHATTERJI, D
FEBS LETTERS, 1992, 306 (01) : 46 - 50

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