Therapeutic Sentinel Lymph Node Imaging

被引：1
作者：
Kachala, Stefan S. [1 ]
Servais, Elliot L. [1 ]
Park, Bernard J. [1 ]
Rusch, Valerie W. [1 ]
Adusumilli, Prasad S. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Div Thorac Surg, 1275 York Ave, New York, NY 10065 USA
来源：
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY | 2009年 / 21卷 / 04期
关键词：
sentinel lymph node; targeted; fluorescent imaging;
D O I：
10.1053/j.semtcvs.2009.11.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Improving existing means of sentinel lymph node identification in non-small cell lung cancer will allow for molecular detection of occult micrometastases that may cause recurrence in early stage non-small cell lung cancer. Furthermore, targeted application of chemical and biological cytotoxic agents can potentially improve outcomes in patients with lymph node (LN) metastases. "Therapeutic Sentinel Lymph Node Imaging" incorporates these modalities into a single agent thereby identifying which LNs harbor tumor cells and simultaneously eradicating metastatic disease. In this review, we summarize the novel preclinical agents for identification and treatment of tumor bearing LNs and discuss their potential for clinical translation. © 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：327 / 338
页数：12
相关论文
共 97 条
[1]   Intraoperative localization of lymph node metastases with a replication-competent herpes simplex virus [J].
Adusumilli, Prasad S. ;
Eisenberg, David P. ;
Stiles, Brendon M. ;
Chung, Sun ;
Chan, Mei-Ki ;
Rusch, Valerie W. ;
Fong, Yuman .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2006, 132 (05) :1179-U62
[2]   Real-time diagnostic imaging of tumors and metastases by use of a replication-competent herpes vector to facilitate minimally invasive oncological surgery [J].
Adusumilli, Prasad S. ;
Stiles, Brendon M. ;
Chan, Mei-Ki ;
Eisenberg, David P. ;
Yu, Zhenkun ;
Stanziale, Stephen F. ;
Huq, Rumana ;
Wong, Richard J. ;
Rusch, Valerie W. ;
Fong, Yuman .
FASEB JOURNAL, 2006, 20 (02) :726-+
[3]   Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma [J].
Adusumilli, Prasad S. ;
Chan, Mei-Ki ;
Hezel, Michael ;
Yu, Zhenkun ;
Stiles, Brendon M. ;
Chou, Ting-Chao ;
Rusch, Valerie W. ;
Fong, Yuman .
ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (01) :258-269
[4]   Virally-directed fluorescent imaging (VFI) can facilitate endoscopic staging [J].
Adusumilli, PS ;
Eisenberg, DP ;
Stiles, BM ;
Hendershott, KJ ;
Stanziale, SF ;
Chan, MK ;
Hezel, M ;
Huq, R ;
Rusch, VW ;
Fong, Y .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2006, 20 (04) :628-635
[5]   Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma [J].
Adusumilli, PS ;
Chan, MK ;
Chun, YS ;
Hezel, M ;
Chou, TC ;
Rusch, VW ;
Fong, YM .
CANCER BIOLOGY & THERAPY, 2006, 5 (01) :48-53
[6]   Lymphoscintigraphy, the sentinel node concept, and the intraoperative gamma probe in melanoma, breast cancer, and other potential cancers [J].
Alazraki, NP ;
Eshima, D ;
Eshima, LA ;
Herda, SC ;
Murray, DR ;
Vansant, JP ;
Taylor, AT .
SEMINARS IN NUCLEAR MEDICINE, 1997, 27 (01) :55-67
[7]   Blood clearance rates of adenovirus type 5 in mice [J].
Alemany, R ;
Suzuki, K ;
Curiel, DT .
JOURNAL OF GENERAL VIROLOGY, 2000, 81 :2605-2609
[8]  
Ayabe Takanori, 2004, Ann Thorac Cardiovasc Surg, V10, P152
[9]   Sentinel lymph node imaging using quantum dots in mouse tumor models [J].
Ballou, Byron ;
Ernst, Lauren A. ;
Andreko, Susan ;
Harper, Theresa ;
Fitzpatrick, James A. J. ;
Waggoner, Alan S. ;
Bruchez, Marcel P. .
BIOCONJUGATE CHEMISTRY, 2007, 18 (02) :389-396
[10]   Targeted drug delivery strategies to treat lung metastasis [J].
Bar, Jair ;
Herbst, Roy S. ;
Onn, Amir .
EXPERT OPINION ON DRUG DELIVERY, 2009, 6 (10) :1003-1016
12345678910