STRUCTURE OF AUREOBASIDIN-A

被引：87

作者：

IKAI, K ^{[1
]}

TAKESAKO, K ^{[1
]}

SHIOMI, K ^{[1
]}

MORIGUCHI, M ^{[1
]}

UMEDA, Y ^{[1
]}

YAMAMOTO, J ^{[1
]}

KATO, I ^{[1
]}

NAGANAWA, H ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 09期

关键词：

D O I：

10.7164/antibiotics.44.925

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106. Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenylalanine. The sequence of the units was identified by NMR and FAB-MS of the products from the alkaline hydrolysis of aureobasidin A.

引用

页码：925 / 933

页数：9

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