STRESS ACTIVATION OF LIMBIC AND CORTICAL DOPAMINE RELEASE IS PREVENTED BY ICS-205-930 BUT NOT BY DIAZEPAM

被引：74

作者：

IMPERATO, A ^{[1
]}

PUGLISIALLEGRA, S ^{[1
]}

ZOCCHI, A ^{[1
]}

SCROCCO, MG ^{[1
]}

CASOLINI, P ^{[1
]}

ANGELUCCI, L ^{[1
]}

机构：

[1] CNR,IST PSICOBIOL & PSICOFARMACOL,ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 02期

关键词：

Diazepam; Dopamine release; ICS; 205-930; Mesocortical dopamine system; Mesolimbic dopamine system; Stress;

D O I：

10.1016/0014-2999(90)90233-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Systemic administration of the 5-HT3 receptor antagonist ICS 205-930, but not of the benzodiazepine diazepam, was able to prevent the stimulation of dopamine release in the nucleus accumbens and prefrontal cortex induced by restraint stress. These findings suggest that stress is not simply co-extensive with anxiety and that 5-HT3 receptors could regulate the dopaminergic response to stress. © 1990.

引用

页码：211 / 214

页数：4

共 10 条

[1]

COSTALL B, 1988, REV NEUROSCI, V2, P41

[2] STRESS-INDUCED INCREASE IN 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) LEVELS IN CEREBRAL-CORTEX AND IN N ACCUMBENS - REVERSAL BY DIAZEPAM [J].