A NOVEL NONPEPTIDIC, ORALLY ACTIVE RENIN INHIBITOR

被引:32
|
作者
MORISHIMA, H [1 ]
KOIKE, Y [1 ]
NAKANO, M [1 ]
ATSUUMI, S [1 ]
TANAKA, S [1 ]
FUNABASHI, H [1 ]
HASHIMOTO, J [1 ]
SAWASAKI, Y [1 ]
MINO, N [1 ]
NAKANO, M [1 ]
MATSUSHIMA, K [1 ]
NAKAMICHI, K [1 ]
YANO, M [1 ]
机构
[1] BANYO PHARMACEUT CO LTD, CENT RES LABS,MEGURO KU, TOKYO 1531, JAPAN
关键词
D O I
10.1016/0006-291X(89)92207-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:999 / 1005
页数:7
相关论文
共 50 条
  • [31] BILA 2157 BS (RI) is a potent, orally active renin inhibitor.
    Panzenbeck, MJ
    Madwed, J
    Harrison, P
    Weldon, SM
    Kerr, S
    Frei, P
    Fogal, SE
    Miner, E
    Desai, S
    Thibeault, D
    Simoneau, B
    Jung, GL
    Lavallee, P
    Anderson, PC
    Winquist, RJ
    FASEB JOURNAL, 1996, 10 (03): : 4030 - 4030
  • [32] Practical synthesis and SAR study of aliskiren: An orally active human renin inhibitor
    Dong, Hua
    Zhang, Zhi-Liu
    Huang, Lia-Hui
    Ma, Rujian
    Chen, Shu-Hui
    Li, Ge
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2696 - U2696
  • [33] Development of orally active nonpeptidic inhibitors of human neutrophil elastase
    Ohmoto, K
    Yamamoto, T
    Okuma, M
    Horiuchi, T
    Imanishi, H
    Odagaki, Y
    Kawabata, K
    Sekioka, T
    Hirota, Y
    Matsuoka, S
    Nakai, H
    Toda, M
    Cheronis, JC
    Spruce, LW
    Gyorkos, A
    Wieczorek, M
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (08) : 1268 - 1285
  • [34] DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN
    HANESSIAN, S
    RAGHAVAN, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (14) : 1697 - 1702
  • [35] Tipranavir - A novel nonpeptidic protease inhibitor
    Ellis, JM
    Ross, JW
    FORMULARY, 2005, 40 (04) : 104 - +
  • [36] Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor
    Nakamura, Yuji
    Fujimoto, Teppei
    Ogawa, Yasuyuki
    Sugita, Chie
    Miyazaki, Shojiro
    Tamaki, Kazuhiko
    Takahashi, Mizuki
    Matsui, Yumi
    Nagayama, Takahiro
    Manabe, Kenichi
    Mizuno, Makoto
    Masubuchi, Noriko
    Chiba, Katsuyoshi
    Nishi, Takahide
    ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (09): : 754 - 758
  • [37] Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Wood, JM
    Maibaum, J
    Rahuel, J
    Grütter, MG
    Cohen, NC
    Rasetti, V
    Rüger, H
    Göschke, R
    Stutz, S
    Fuhrer, W
    Schilling, W
    Rigollier, P
    Yamaguchi, Y
    Cumin, F
    Baum, HP
    Schnell, CR
    Herold, P
    Mah, R
    Jensen, C
    O'Brien, E
    Stanton, A
    Bedigian, MP
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (04) : 698 - 705
  • [38] MACROCYCLIC RENIN INHIBITORS - SYNTHESIS OF A SUBNANOMOLAR, ORALLY-ACTIVE CYSTEINE DERIVED INHIBITOR
    YANG, LH
    WEBER, AE
    GREENLEE, WJ
    PATCHETT, AA
    TETRAHEDRON LETTERS, 1993, 34 (44) : 7035 - 7038
  • [39] AN ORALLY ACTIVE RENIN INHIBITOR - CYCLOHEXYLNORSTATINE-CONTAINING DIPEPTIDE (KRI-1314)
    MIYAZAKI, M
    ETOH, Y
    IIZUKA, K
    TODA, N
    JOURNAL OF HYPERTENSION, 1989, 7 : S25 - S27
  • [40] FK-906, A HIGHLY POTENT, ORALLY-ACTIVE HUMAN RENIN INHIBITOR
    NEYA, M
    MARUSAWA, H
    IMAL, K
    KAYAKIRI, N
    WATANABE, S
    HEMML, K
    HASHIMOTO, M
    TANAKA, H
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 56 - MEDI