HIGH PREVALENCE OF OCCULT PAPILLARY THYROID-CARCINOMA IN A SURGICAL SERIES FOR BENIGN THYROID-DISEASE

被引:74
|
作者
PELIZZO, MR
PIOTTO, A
RUBELLO, D
CASARA, D
FASSINA, A
BUSNARDO, B
机构
[1] UNIV PADUA,IST SEMEIOT MED,VIA OSPED 105,I-35100 PADUA,ITALY
[2] UNIV PADUA,IST ANAT PATOL,CATTEDRA 3,I-35100 PADUA,ITALY
[3] OSPED PADUA,DIV RADIOTERAPIA & MED NUCL,PADUA,ITALY
关键词
D O I
10.1177/030089169007600309
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In a surgical series of 277 consecutive patients operated on the thyroid for benign diseases, a high prevalence rate (10.5%) of occult papillary carcinoma was found by means of an accurate histologic examination. Indications for surgery were euthyroid multinodular goiter in 25 patients, autonomously hyperfunctioning adenoma in 2 and Graves' disease in 2 patients. Neoplastic foci were unilaterally found in 25 cases but multifocally in 6 and bilaterally in 4 cases: the diameters ranged from 2-10 mm. After operation (14 subtotal and 15 total thyroidectomies), all patients received TSH-suppressive doses of T4. At a mean follow-up of 5.6 years, neither local recurrences nor lymph node or distant metastases had occurred; no patient died of the tumor. In keeping with other surgical and autopsy series, the prevalence of occult thyroid carcinoma in a normal population is calculated to be about 5-10%, whereas it is known that the prevalence of clinically evident thyroid cancer is only 0.05%. This means that only 1-2% of occult carcinomas may evolve in an overt tumor during life. In view of such an epidemiologic difference and the favorable course of our patients, although the mean follow-up is rather short, we suggest that lobectomy plus T4 treatment may be considered an adequate therapeutic approach in patients with occult papillary thyroid carcinoma.
引用
收藏
页码:255 / 257
页数:3
相关论文
共 50 条
  • [41] LOCAL RECURRENCE IN PAPILLARY THYROID-CARCINOMA - IS EXTENT OF SURGICAL RESECTION IMPORTANT
    GRANT, CS
    HAY, ID
    GOUGH, IR
    BERGSTRALH, EJ
    GOELLNER, JR
    MCCONAHEY, WM
    SURGERY, 1988, 104 (06) : 954 - 962
  • [42] The incidence of occult papillary thyroid carcinomas in patients with benign thyroid nodules
    Williams, M. D.
    Suliburk, J. W.
    Staerkel, G. A.
    Busaidy, N. L.
    Lee, J. E.
    Clayman, G. L.
    Evans, D. B.
    Perrier, N. D.
    MODERN PATHOLOGY, 2008, 21 : 111A - 111A
  • [43] The incidence of occult papillary thyroid carcinomas in patients with benign thyroid nodules
    Williams, M. D.
    Suliburk, J. W.
    Staerkel, G. A.
    Busaidy, N. L.
    Lee, J. E.
    Clayman, G. L.
    Evans, D. B.
    Perrier, N. D.
    LABORATORY INVESTIGATION, 2008, 88 : 111A - 111A
  • [44] PREGNANCY AND SURGICAL THYROID-DISEASE
    ROSEN, IB
    WALFISH, PG
    NIKORE, V
    SURGERY, 1985, 98 (06) : 1135 - 1140
  • [45] SURGICAL STRATEGY IN THYROID-DISEASE
    WATKINSON, JC
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1992, 118 (04) : 447 - 448
  • [46] SURGICAL STRATEGY IN THYROID-DISEASE
    LANDO, MJ
    HOOVER, LA
    ZUCKERBRAUN, L
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1990, 116 (12) : 1378 - 1383
  • [47] OCCULT THYROID-CARCINOMA AT AUTOPSY IN MALMO, SWEDEN
    BONDESON, L
    LJUNGBERG, O
    CANCER, 1981, 47 (02) : 319 - 323
  • [48] THE TALL CELL VARIANT OF PAPILLARY THYROID-CARCINOMA - COMPARISON WITH THE COMMON FORM OF PAPILLARY THYROID-CARCINOMA BY DNA AND MORPHOMETRIC ANALYSIS
    FLINT, A
    DAVENPORT, RD
    LLOYD, RV
    LABORATORY INVESTIGATION, 1990, 62 (01) : A34 - A34
  • [49] Intrathoracic papillary thyroid carcinoma from occult primary disease
    Oikonomou A.
    Astrinakis E.
    Giatromanolaki A.
    Karros P.
    Margaritis D.
    Prassopoulos P.
    General Thoracic and Cardiovascular Surgery, 2014, 62 (3) : 198 - 201