Synthesis and structural characterization of some lipoxygenase-inhibiting O-aryl-O-phenyl carbonates

被引：0

作者：

Abbasi, M. A. ^{[1
]}

Khan, F. M. ^{[1
]}

Aziz-ur-rehman ^{[1
]}

Muhmood, T. ^{[1
]}

Khan, K. M. ^{[2
]}

Ashraf, M. ^{[3
]}

Afzal, I ^{[4
]}

Ambreen, N. ^{[2
]}

机构：

[1] Govt Coll Univ, Dept Chem, Lahore 54000, Pakistan

[2] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[3] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur, Pakistan

[4] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur, Pakistan

来源：

BIOSCIENCE RESEARCH | 2012年 / 9卷 / 01期

关键词：

O-aryl-O-phenyl carbonates; phenyl chloroformate; phenols; acetylcholinesterase; lipoxygenase;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A practically simple method for the production of various O-aryl-O-phenyl carbonates was executed by treating different phenols (2a-g) with phenyl chloroformate (1) in basic solution with the resultant production of title carbonates (3a-g). The structures of these carbonates were confirmed through their 1H-NMR spectra. These were screened against acetylcholinesterase, butyrylcholinesterase and lipoxygenase enzymes and all were found to be good inhibitors of lipoxygenase except 3e. However, 3c and 3f were also active against acetylcholinesterase enzyme.

引用

页码：30 / +

页数：6