GLUCOSE, SULFONYLUREAS, AND NEUROTRANSMITTER RELEASE - ROLE OF ATP-SENSITIVE K+ CHANNELS

被引：408

作者：

AMOROSO, S ^{[1
]}

SCHMIDANTOMARCHI, H ^{[1
]}

FOSSET, M ^{[1
]}

LAZDUNSKI, M ^{[1
]}

机构：

[1] CNRS,UPR 411,INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE

来源：

SCIENCE | 1990年 / 247卷 / 4944期

关键词：

D O I：

10.1126/science.2305257

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sulfonylurea-sensitive adenosine triphosphate (ATP)-regulated potassium (KATP) channels are present in brain cells and play a role in neurosecretion at nerve terminals. KATP channels in substantia nigra, a brain region that shows high sulfonylurea binding, are inactivated by high glucose concentrations and by antidiabetic sulfonylureas and are activated by ATP depletion and anoxia. KATP channel inhibition leads to activation of γ-aminobutyric acid (GABA) release, whereas KATP channel activation leads to inhibition of GABA release. These channels may be involved in the response of the brain to hyper- and hypoglycemia (in diabetes) and ischemia or anoxia.

引用

页码：852 / 854

页数：3

共 22 条

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