NALORPHINE - INCREASED SENSITIVITY OF MONKEYS FORMERLY DEPENDENT ON MORPHINE

被引：52

作者：

GOLDBERG, SR

SCHUSTER, CR

机构：

[1] Department of Pharmacology, University of Michigan Medical School, Ann Arbor

[2] Department of Psychiatry, University of Chicago, Chicago

来源：

SCIENCE | 1969年 / 166卷 / 3912期

关键词：

D O I：

10.1126/science.166.3912.1548

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls.

引用

页码：1548 / &

共 6 条

[1]

COCHIN J, 1964, J PHARMACOL EXP THER, V145, P1

[2]

FRASER HF, 1952, J PHARMACOL EXP THER, V105, P498

[3] Clinical studies of drug addiction - Physical dependence, withdrawal and recovery [J].