EXPRESSION OF MOUSE AND HUMAN FIBRONECTIN IN MOUSE-HUMAN SOMATIC-CELL HYBRIDS

被引：8

作者：

ZARDI, L ^{[1
]}

CARNEMOLLA, B ^{[1
]}

CROCE, CM ^{[1
]}

机构：

[1] UNIV PENN, WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 118卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90174-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using antisera to the human and mouse fibronectin (Large External Transformation Sensitive (LETS) protein), we studied the expression of mouse and human fibronectin in mouse-human somatic cell hybrids segregating either human or mouse chromosomes. The results of this study show that, in such somatic cell hybrids, mouse and human fibronectin are coexpressed. In addition, activation of the synthesis of mouse fibronectin was observed in somatic cell hybrids between mouse peritoneal macrophages, which do not produce detectable amounts of fibronectin, and either SV40-transformed human cells or cells derived from a human fibrosarcoma. © 1979.

引用

页码：435 / 438

页数：4

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