DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF CLONIDINE IN RATS CROSS-TOLERANCE TO MORPHINE

被引：93
作者：
PAALZOW, G
机构：
[1] Department of Pharmacology, Pharmaceutical Faculty, University of Uppsala, Biomedical Center, Uppsala, S-751 23
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1978年 / 304卷 / 01期
关键词：
Analgesia; Clonidine; Morphine; Tolerance;
D O I：
10.1007/BF00501369
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of chronic treatment with clonidine on analgesia produced by clonidine and morphine was studied in rats. Electrical stimuli were applied to the tail, and analgesia was measured as increase in the threshold voltage that elicited vocalisation. Twentytwo hours after the last of 14 injections of increasing doses of clonidine over 7 days, the acute analgesic effects of both clonidine and morphine were reduced, i.e. tolerance had developed. Pretest vocalisation thresholds (voltage) were unchanged by long-term treatment with clonidine or, respectively, saline. Contrarywise, acute administration of clonidine enhanced the effect of morphine. The tolerance developed after long-term treatment with clonidine might be associated with changes in brain noradrenaline mechanisms. © 1978 Springer-Verlag.
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页码：1 / 4
页数：4
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