LOSS OF STRIATAL HIGH-AFFINITY NGF BINDING-SITES IN PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT IN PARKINSONS-DISEASE

被引：11

作者：

VILLARES, J ^{[1
]}

STRADA, O ^{[1
]}

FAUCHEUX, B ^{[1
]}

JAVOYAGID, F ^{[1
]}

AGID, Y ^{[1
]}

HIRSCH, EC ^{[1
]}

机构：

[1] ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,SAO PAULO,BRAZIL

来源：

NEUROSCIENCE LETTERS | 1994年 / 182卷 / 01期

关键词：

CHOLINERGIC NEURON; NERVE GROWTH FACTOR; PARKINSONS DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(94)90205-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

I-125-Nerve growth factor (NGF) binding sites were analyzed by autoradiography in the striatum of 3 central subjects, 3 patients with Parkinson's disease and 3 patients with progressive supranuclear palsy. A high level of I-125-NGF binding was observed (0.3-0.4 fmol/mg of tissue equivalent) in the striatum and the nucleus basalis of Meynert of control patients. Pockets of lower I-125-NGF binding corresponding to acetylcholinesterase-poor striosomes were detected in the striatum of control subjects and patients with Parkinson's disease or progressive supranuclear palsy. When compared to controls, the density of I-125-NGF binding sites was reduced by 30% in the striatum of patients with progressive supranuclear palsy but not reduced in that of patients with Parkinson's disease. I-125-NGF binding was not significantly decreased in the nucleus basalis of Meynert in either diseases. Since NGF receptors are thought to be localized on cholinergic neurons in the striatum, the decrease in NGF binding is compatible with the loss of cholinergic neurons reported in the striatum from PSP patients.

引用

页码：59 / 62

页数：4

共 19 条

[1] DIFFERENTIAL VULNERABILITY OF CHOLINERGIC PROJECTIONS TO THE MEDIODORSAL NUCLEUS OF THE THALAMUS IN SENILE DEMENTIA OF ALZHEIMER TYPE AND PROGRESSIVE SUPRANUCLEAR PALSY [J].