PLASMODIUM-FALCIPARUM - DETECTION OF P-GLYCOPROTEIN IN CHLOROQUINE-SUSCEPTIBLE AND CHLOROQUINE-RESISTANT CLONES AND ISOLATES

被引：19
作者：
CREMER, G
BASCO, LK
LEBRAS, J
CAMUS, D
SLOMIANNY, C
机构：
[1] UNIV LYON 1,HOP BICHAT,PARASITOL LAB,F-75877 PARIS,FRANCE
[2] INSERM,U42,F-59651 VILLENEUVE DASCQ,FRANCE
来源：
EXPERIMENTAL PARASITOLOGY | 1995年 / 81卷 / 01期
关键词：
D O I：
10.1006/expr.1995.1086
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Recent studies have suggested the potential involvement of multidrug resistance (mdr) genes in resistance to quinoline-containing compounds in Plasmodium falciparum parasites. Three different antibodies were used to detect the malarial mdr 1 protein product by indirect immunofluorescence and/or immunoblot in fresh clinical isolates and clones of P. falciparum from different geographic origins. A 160-kDa protein was detected in all five parasite clones by immunoblot and around the food vacuole by IFA, regardless of the level of sensitivity to chloroquine and the modulation by desipramine of chloroquine accumulation. Our results suggest that chloroquine resistance is not correlated with the presence of the Pfmdr1 product. (C) 1995 Academic Press. Inc.
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页码：1 / 8
页数：8
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