MOLLIFICATION OF CYTOTOXICITY OF SULFATED POLYSACCHARIDES BY FIBROBLAST GROWTH-FACTORS

被引：1
作者：
KUNOU, M [1 ]
OHTSUKI, T [1 ]
AKAIKE, T [1 ]
HATANAKA, K [1 ]
机构：
[1] TOKYO INST TECHNOL,DEPT BIOMOLEC ENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 1995年 / 14卷 / 4-5期
关键词：
D O I：
10.1080/07328309508005367
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sulfated polysaccharide which had a relatively high degree of sulfation showed cytotoxicity to 3T3-L1 fibroblasts. Acidic and basic fibroblast growth factors inhibited the cell damage caused by the sulfated polysaccharides, while epidermal growth factor and platelet growth factor had no effects.
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页码：659 / 665
页数：7
相关论文
共 26 条
  • [1] APOPTOSIS OF VASCULAR ENDOTHELIAL-CELLS BY FIBROBLAST GROWTH-FACTOR DEPRIVATION
    ARAKI, S
    SHIMADA, Y
    KAJI, K
    HAYASHI, H
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 168 (03) : 1194 - 1200
  • [2] BASIC FIBROBLAST GROWTH-FACTOR BINDS TO SUBENDOTHELIAL EXTRACELLULAR-MATRIX AND IS RELEASED BY HEPARITINASE AND HEPARIN-LIKE MOLECULES
    BASHKIN, P
    DOCTROW, S
    KLAGSBRUN, M
    SVAHN, CM
    FOLKMAN, J
    VLODAVSKY, I
    [J]. BIOCHEMISTRY, 1989, 28 (04) : 1737 - 1743
  • [3] THE HEPARIN-BINDING (FIBROBLAST) GROWTH-FACTOR FAMILY OF PROTEINS
    BURGESS, WH
    MACIAG, T
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 : 575 - 606
  • [4] CARPENTER G, 1987, ANNU REV BIOCHEM, V56, P881, DOI 10.1146/annurev.bi.56.070187.004313
  • [5] HEPARIN POTENTIATES THE ACTION OF ACIDIC FIBROBLAST GROWTH-FACTOR BY PROLONGING ITS BIOLOGICAL HALF-LIFE
    DAMON, DH
    LOBB, RR
    DAMORE, PA
    WAGNER, JA
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (02) : 221 - 226
  • [6] BASIC FIBROBLAST GROWTH-FACTOR RESCUES CNS NEURONS FROM CELL-DEATH CAUSED BY HIGH OXYGEN ATMOSPHERE IN CULTURE
    ENOKIDO, Y
    AKANEYA, Y
    NIINOBE, M
    MIKOSHIBA, K
    HATANAKA, H
    [J]. BRAIN RESEARCH, 1992, 599 (02) : 261 - 271
  • [7] EXTRACELLULAR-MATRIX HEPARAN-SULFATE PROTEOGLYCANS MODULATE THE MITOGENIC CAPACITY OF ACIDIC FIBROBLAST GROWTH-FACTOR
    GORDON, PB
    CHOI, HU
    CONN, G
    AHMED, A
    EHRMANN, B
    ROSENBERG, L
    HATCHER, VB
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 140 (03) : 584 - 592
  • [8] HEPARIN PROTECTS BASIC AND ACIDIC FGF FROM INACTIVATION
    GOSPODAROWICZ, D
    CHENG, J
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1986, 128 (03) : 475 - 484
  • [9] HAIMOVITZFRIEDM.A, 1991, CANCER RES, V51, P2552
  • [10] A STRONG INHIBITION OF HIV-INDUCED CYTOPATHIC EFFECTS BY SYNTHETIC (1-]6)-ALPHA-D-MANNOPYRANAN SULFATE
    HATANAKA, K
    KURIHARA, Y
    URYU, T
    YOSHIDA, O
    YAMAMOTO, N
    MIMURA, T
    KANEKO, Y
    [J]. CARBOHYDRATE RESEARCH, 1991, 214 (01) : 147 - 154
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