EFFECTS OF DIHYDROPYRIDINES ON CEREBRAL BLOOD-VESSELS

被引：0
作者：
KURIYAMA, Y
HASHIMOTO, H
NAGATSUKA, K
SAWADA, T
OMAE, T
机构：
来源：
JOURNAL OF HYPERTENSION | 1993年 / 11卷
关键词：
STROKE; CEREBRAL CIRCULATION; HYPERTENSION; NICARDIPINE; NIFEDIPINE RETARD; DIHYDROPYRIDINE; CALCIUM ANTAGONIST;
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Aim: To evaluate the effects of dihydropyridine calcium antagonists on the cerebral circulation in stroke patients. Design of studies: Mean cerebral circulation parameters were studied in chronic stroke patients with hypertension and treated acutely or chronically (2 weeks) with nicardipine or nifedipine retard. The effects of nicardipine on local cerebral blood flow were also studied in patients with a subacute brain infarction. Results: Mean cerebral blood flow was significantly increased after a single oral administration of nicardipine but not after nifedipine retard. Both calcium antagonists reduced mean arterial pressure. Nifedipine retard acted mainly by reducing blood pressure and nicardipine mainly by reducing cerebrovascular resistance. Conclusion: Dihydropyridines have a beneficial effect in the control of hypertension in stroke patients.
引用
收藏
页码：S9 / S12
页数：4
相关论文
共 50 条
  • [41] Extracellular SOD and aged blood vessels
    Fukai, Tohru
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2009, 297 (01): : H10 - H12
  • [42] Early pathophysiological changes in cerebral vessels predisposing to stroke
    Gerzanich, V
    Ivanova, S
    Simard, JM
    CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2003, 29 (3-4) : 291 - 294
  • [43] Peculiarities of vasomotor reaction of cerebral vessels in arterial hypertension
    B. I. Gel’tser
    V. N. Kotel’nikov
    I. G. Agafonova
    P. A. Luk’yanov
    M. V. Antonyuk
    T. P. Novgorodtseva
    Bulletin of Experimental Biology and Medicine, 2007, 144 : 33 - 35
  • [44] Peculiarities of vasomotor reaction of cerebral vessels in arterial hypertension
    Gel'tser, B. I.
    Kotel'nikov, V. N.
    Agafonova, I. G.
    Luk'yanov, P. A.
    Antonyuk, M. V.
    Novgorodtseva, T. P.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (01) : 33 - 35
  • [45] CEREBRAL BLOOD-FLOW, CEREBRAL BLOOD-FLOW REACTIVITY TO ACETAZOLAMIDE, AND CEREBRAL BLOOD-VOLUME IN PATIENTS WITH LEUKOARAIOSIS
    TURC, JD
    CHOLLET, F
    BERRY, I
    SABATINI, U
    DEMONET, JF
    CELSIS, P
    MARCVERGNES, JP
    RASCOL, A
    CEREBROVASCULAR DISEASES, 1994, 4 (04) : 287 - 293
  • [46] Effects of chloride substitution in isolated mesenteric blood vessels from Dahl normotensive and hypertensive rats
    Parai, K
    Tabrizchi, R
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2005, 46 (01) : 105 - 114
  • [47] The Effects of Flumazenil After Midazolam Sedation on Cerebral Blood Flow and Dynamic Cerebral Autoregulation in Healthy Young Males
    Ogawa, Yojiro
    Iwasaki, Ken-ichi
    Aoki, Ken
    Yanagida, Ryo
    Ueda, Kaname
    Kato, Jitsu
    Ogawa, Setsuro
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2015, 27 (04) : 275 - 281
  • [48] Incomplete recovery of cerebral blood flow dynamics in sufficiently treated high blood pressure
    Mueller, Martin
    Osterreich, Mareike
    von Hessling, Alexander
    Smith, Roy S.
    JOURNAL OF HYPERTENSION, 2019, 37 (02) : 372 - 379
  • [49] REGULATION OF CEREBRAL BLOOD-FLOW IN HEALTH AND DISEASE
    STRANDGAARD, S
    PAULSON, OB
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 19 : S89 - S93
  • [50] Concurrent Variations of Cerebral Blood Flow and Arterial Blood Pressure in Simulated Sleep Apnea
    Alex, Raichel
    Bhave, Gauri
    Al-Abed, Mohammad A.
    Bashaboyina, Aditya
    Iyer, Swathi
    Watenpaugh, Donald E.
    Zhang, Rong
    Behbehani, Khosrow
    2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2011, : 3209 - 3212
12345