THE TANDEM MICHAEL-S(N)2 REACTION FOR THE CONSTRUCTION OF THE 3-AZABICYCLO[3.1.0]HEXANE RING-SYSTEM

被引：21

作者：

CHAN, S ^{[1
]}

BRAISH, TF ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,PROC RES & DEV,GROTON,CT 06340

来源：

TETRAHEDRON | 1994年 / 50卷 / 33期

关键词：

INTRAMOLECULAR MICHAEL; INTRAMOLECULAR S(N)2; 3-AZABICYCLO[3.1.0]HEXANE; 3-AZABICYCLO[4.1.0]HEPTANE; DICHLOROACETIC ACID;

D O I：

10.1016/S0040-4020(01)89609-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 3-azabicyclo[3.1.0]-hexane ring system was constructed in a convergent one-pot procedure starting from readily available starting materials, using the intramolecular tandem Michael-S(N)2 reaction. The methodology was also extended to the synthesis of 3-azabicyclo[4.1.0]heptane ring system.

引用

页码：9943 / 9950

页数：8