STRUCTURE, SEQUENCE, AND CHROMOSOMAL LOCATION OF THE GENE FOR USF2 TRANSCRIPTION FACTORS IN MOUSE

被引:35
|
作者
HENRION, AA [1 ]
MARTINEZ, A [1 ]
MATTEI, MG [1 ]
KAHN, A [1 ]
RAYMONDJEAN, M [1 ]
机构
[1] HOP ENFANTS LA TIMONE, INSERM, U406, F-13385 MARSEILLE, FRANCE
关键词
D O I
10.1016/0888-7543(95)80107-W
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The ubiquitously expressed upstream stimulatory factor (USF) involved in the transcription of a wide variety of cellular genes is defined as dimers of c-myc-related proteins, composed of a basic helix-loop-helix/leucine zipper region. The USF family consists of different members that split into two groups: MLTF or USF1 and USF2 or FIP. We present here evidence that USF1 and USF2 are distinct closely related genes in human, rat, and mouse. Based on the recent cloning of rat and human new cDNAs, we have isolated genomic clones encompassing the murine USF2 gene, which consists of at least 10 exons spanning a minimum of 10 kb of genomic DNA. Unexpectedly, the organization of USF2 appears very split up by introns (0.08 to over 6 kb in size), compared to the myc gene structure. The entire gene (but the larger intron) and 1.6 kb of the 5' flanking region were sequenced. This 5' flanking region is GC-rich, contains several putative transcription binding sites, and has no apparent TATA box. Gene mapping of murine USF2 and USF1 has been determined by in situ hybridization, indicating the localization of USF2 on chromosome 7 and of USF1 on chromosomes 1 and 11. (C) 1995 Academic Press, Inc.
引用
收藏
页码:36 / 43
页数:8
相关论文
共 50 条
  • [41] O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2
    Jiang, B
    Mendelson, CR
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (20) : 8824 - 8833
  • [42] Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the Adenomatous polyposis coli (APC) tumor suppressor gene
    Jaiswal, AS
    Narayan, S
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2001, 81 (02) : 262 - 277
  • [43] Identification of USF2 as a key regulator of Runx2 expression in mouse pluripotent mesenchymal D1 cells
    Wang, Chihuei
    Lee, Grace
    Hsu, Wayne
    Yeh, Ching-Hua
    Ho, Mei-Ling
    Wang, Gwo-Jaw
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2006, 292 (1-2) : 79 - 88
  • [44] Identification of USF2 as a key regulator of Runx2 expression in mouse pluripotent mesenchymal D1 cells
    Chihuei Wang
    Grace Lee
    Wayne Hsu
    Ching-Hua Yeh
    Mei-Ling Ho
    Gwo-Jaw Wang
    Molecular and Cellular Biochemistry, 2006, 292 : 79 - 88
  • [45] STRUCTURE AND CHROMOSOMAL LOCATION OF THE GENE ENCODING MOUSE CORTICOSTEROID-BINDING GLOBULIN - STRAIN DIFFERENCES IN CODING SEQUENCE AND STEROID-BINDING ACTIVITY
    ORAVA, M
    ZHAO, XF
    LEITER, E
    HAMMOND, GL
    GENE, 1994, 144 (02) : 259 - 264
  • [46] GSK3β-Dependent Phosphorylation Alters DNA Binding, Transactivity and Half-Life of the Transcription Factor USF2
    Horbach, Tina
    Chi, Tabughang Franklin
    Goetz, Claudia
    Sharma, Satyan
    Juffer, Andre H.
    Dimova, Elitsa Y.
    Kietzmann, Thomas
    PLOS ONE, 2014, 9 (09):
  • [47] Location of the DBP transcription factor gene in human and mouse
    Stubbs, L
    Carver, E
    Ashworth, L
    LopezMolina, L
    MAMMALIAN GENOME, 1996, 7 (01) : 65 - 67
  • [48] Functional domains of the transcription factor USF2: Atypical nuclear localization signals and context-dependent transcriptional activation domains
    Luo, X
    Sawadogo, M
    MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (04) : 1367 - 1375
  • [49] Oxygen stimulation of proteasomal degradation of USF1 and USF2 mediates human trophoblast differentiation and induction of CYP19 gene expression.
    Jiang, B
    Mendelson, CR
    JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2004, 11 (02) : 178A - 178A
  • [50] Sequence, genomic organization, and chromosomal location of the mouse Mullerian-inhibiting substance type II receptor gene
    Mishina, Y
    Tizard, R
    Deng, JM
    Pathak, BG
    Copeland, NG
    Jenkins, NA
    Cate, RL
    Behringer, RR
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (03) : 741 - 746